Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis
Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis
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DOI：
10.1097/mca.0b013e3283452431
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发表时间：
2011-06-01
影响因子：
1.8
通讯作者：
Abd-Elsayed, Alaa
中科院分区：
文献类型：
--
作者：
Hasan-Ali, Hosam;El-Mottaleb, Nashwa A. Abd;Abd-Elsayed, Alaa
背景脂联素和瘦素与冠状动脉粥样硬化程度的关系尚未得到很好的阐明。本研究旨在探讨血清脂联素和瘦素与冠状动脉粥样硬化的关系。冠状动脉粥样硬化的血管造影评价是通过评估三个动脉粥样硬化指标，（横向疾病），程度（纵向疾病）和模式结果动脉粥样硬化严重程度的独立预测因素为较大的腰/臀比，其次为较高的低密度脂蛋白胆固醇、较低的血清脂联素水平、年龄较大、较高的瘦素水平、目前存在不稳定型心绞痛、最后是先前的心肌梗死（MI）。如模型调整后的r（2）（50%）所示，该模型是一个很好的模型。对于程度指数，较低的血清脂联素水平是迄今为止最重要的独立预测因子，其次是较高的低密度脂蛋白胆固醇、年龄较大和既往MI，而较高的血清瘦素水平只是一个单变量预测因子。模型调整后的r（2）为65%。对于模式指数，独立的预测因素是既往MI、较低的血清脂联素水平、较大的腰/臀比、较高的血清瘦素水平、年龄较大和较高的空腹血糖水平。结论血清脂联素和瘦素在冠心病的发生、病变的严重程度、范围和复杂程度中均起重要的致病作用。科龙动脉病变22：264-269（C）2011年沃尔特斯·克鲁沃健康垂直酒吧利平科特威廉姆斯&威尔金斯。
Background The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis.Methods Seventy patients and 20 matched controls were recruited. Angiographic evaluation of coronary atherosclerosis was carried out by assessing three atherosclerotic indices, severity (transverse disease), extent (longitudinal disease), and pattern (lesion complexity).Results The independent predictors of atherosclerosis severity were larger waist/hip ratio, followed by higher low-density lipoprotein-cholesterol, low serum adiponectin level, older age, higher leptin level, current unstable angina, and finally previous myocardial infarction (MI). This model is a good one as indicated by the model-adjusted r(2) (50%). For extent index, lower serum adiponectin level was by far the most important independent predictor, followed by higher low-density lipoprotein-cholesterol, older age, and previous MI, whereas higher serum leptin level was only a univariate predictor. The model-adjusted r(2) was 65%. For pattern index, the independent predictors were previous MI, lower serum adiponectin level, larger waist/hip ratio, higher serum leptin level, older age, and higher fasting blood glucose level. The model-adjusted r(2) was 62%.Conclusion Both serum adiponectin and leptin might play an important pathogenic role not only in the occurrence but also in the severity, extent, and lesion complexity in coronary artery disease patients. Coron Artery Dis 22:264-269 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.