Differences in pO2 peaks of a murine fibrosarcoma between carbon-ion and X-ray irradiation
Differences in pO2 peaks of a murine fibrosarcoma between carbon-ion and X-ray irradiation
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DOI：
10.1269/jrr.45.303
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发表时间：
2004-06-01
影响因子：
2
通讯作者：
Tanishita, K
中科院分区：
文献类型：
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作者：
Fukawa, T;Takematsu, K;Tanishita, K
我们测量和比较了实验肿瘤经碳离子和X射线照射后的氧分压(Po(2))分布。C3H型雄性小鼠后肢NFSA纤维肉瘤经单次碳离子或X射线照射后，均有相同的疗效。用计算机显微操作机将空间分辨率高的同轴氧气微电极按20步置入肿瘤内。在未照射的肿瘤中，达到15毫米汞的Po(2)峰的数目至少为每3,000微米0.45个，并且在碳离子照射的第一天就显著增加到每3,000微米1.55个(p<；0.001)。接受X射线照射的肿瘤的Po(2)峰也明显增加，但最晚出现在第3天。本研究中Po(2)峰出现的时间进程与先前报道的用配对生长延迟实验测量复氧的时间过程一致。在X射线照射的肿瘤组织中，Po(2)峰有选择性地出现在肿瘤周围区域，而在碳离子照射后的肿瘤组织中，Po(2)峰出现得比较均匀。结论：碳离子照射对NFSA纤维肉瘤的复氧作用比X射线照射更早，在空间上更深。
We measured and compared the oxygen partial pressure (pO(2)) profiles in experimental tumors after irradiation with carbon ions and with X-rays. The NFSa fibrosarcomas grown in the hind legs of C3H male mice received isoeffect single doses of carbon ions or X-rays. Coaxial oxygen microelectrodes of high spatial resolution were inserted into the tumor with 20 put steps by a computerized micromanipulator. The number of pO(2) peaks that reached 15 mmHg were at least 0.45 per 3,000 mum in unirradiated tumors and significantly increased to 1.55 per 3,000 put as early as day 1 of carbon-ion irradiation (p < 0.001). The tumors that received X-ray irradiation also significantly increased pO(2) peaks, but as late as day 3. The time course of pO(2) peak appearance in the present study coincides with a previous report where reoxygenation was measured by paired growth delay assay. The pO(2) peaks appeared selectively in peripheral regions of X-ray irradiated tumors, but they appeared rather homogeneously in the tumor after carbon-ion irradiation. It is concluded that carbon-ion irradiation reoxygenated the NFSa fibrosarcomas earlier in time and deeper in space than the Xray irradiation did.