Paracetamol sales and atopic disease in children and adults: an ecological analysis
Paracetamol sales and atopic disease in children and adults: an ecological analysis
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DOI：
10.1183/09031936.00.16581700
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发表时间：
2000-11-01
影响因子：
24.3
通讯作者：
Burney, PGJ
中科院分区：
文献类型：
--
作者：
Newson, RB;Shaheen, SO;Burney, PGJ
作者最近观察到，频繁使用扑热息痛与年轻人的哮喘和鼻炎呈正相关。因此，进行了生态分析，以衡量扑热息痛销售与儿童和成人特应性疾病患病率之间的国际关联。国际儿童哮喘和过敏研究（ISAAC）公布的13-14岁儿童四种特应性症状患病率数据（112个中心）和6-7岁儿童1994/1995年（66个中心）和欧洲共同体呼吸健康调查（ECRHS）关于哮喘症状、确诊哮喘和鼻炎流行率的数据使用1991/1992年在年轻成人中（44个中心），特应性患病率，平均支气管反应性和平均总免疫球蛋白E水平（34个中心）。对乙酰氨基酚在英语国家的销售量较高，与13-14岁儿童的哮喘症状、湿疹和过敏性鼻结膜炎呈正相关，与成人的喘息、确诊哮喘、鼻炎和支气管反应性呈正相关。13-14岁儿童喘息患病率增加0.52%，成人增加0.26%（P
The authors recently observed that frequent paracetamol use was positively associated with asthma and rhinitis in young adults. Therefore, an ecological analysis was performed to measure international associations between paracetamol sales and atopic disease prevalences in children and adults.Published data from the International Study of Asthma and Allergies in Childhood (ISAAC) on the prevalence of four atopic symptoms in 13-14-yr-olds (112 centres) and 6-7-yr-olds (66 centres) in 1994/1995, and European Community Respiratory Health Survey (ECRHS) data on the prevalence of asthma symptoms, diagnosed asthma and rhinitis (44 centres), prevalence of atopy, mean bronchial responsiveness and mean total immunoglobulin E levels (34 centres) in young adults in 1991/1992, were used. Their associations with national 1994/1995 per capita paracetamol sales were measured using linear regression.Paracetamol sales were high in English-speaking countries, and were positively associated with asthma symptoms, eczema and allergic rhinoconjunctivitis in 13-14-yr-olds, and with wheeze, diagnosed asthma, rhinitis and bronchial responsiveness in adults. The prevalence of wheeze increased by 0.52% in 13-14-yr-olds and by 0.26% in adults (p