The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons.
The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons.
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DOI：
10.1016/j.neurobiolaging.2010.09.025
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发表时间：
2012-02
影响因子：
4.2
通讯作者：
Greig NH
中科院分区：
文献类型：
--
作者：
Mouton PR;Kelley-Bell B;Tweedie D;Spangler EL;Perez E;Carlson OD;Short RG;deCabo R;Chang J;Ingram DK;Li Y;Greig NH
帕金森病（Parkinson's disease，PD）是一种与年龄相关的运动障碍性疾病，以黑质腹侧被盖区（substantia nigra pars-ventral tegmental area，SNPC-VTA）和蓝斑（locus bluleus，LC）的儿茶酚胺能神经元严重缺失为特征。为了评估严重炎症急性发作后这些中枢儿茶酚胺能神经元的稳定性，6至22月龄的C57/B16小鼠接受最大耐受剂量的LPS，然后在两小时后安乐死以测定外周和中枢细胞因子的峰值水平;并且在14周后用于SNPC-VTA和LC中酪氨酸羟化酶免疫阳性（TH+）神经元的计算机体视学。LPS后两小时，细胞因子水平以年龄相关的方式变化，老年和年轻小鼠的外周和中央升高最大。严重的炎症未能引起SNPC-VTA或LC中TH+神经元的损失;然而，在LPS处理组和对照组中，这些TH+神经元存在年龄相关性下降。因此，B6小鼠脑中的未知机制似乎在严重炎症的急性发作期间防止儿茶酚胺能神经元损失，而儿茶酚胺能神经元损失发生在正常衰老期间。
Parkinson’s disease (PD), an age-related movement disorder, is characterized by severe catecholaminergic neuron loss in the substantia nigra pars compacta-ventral tegmental area (SNPC-VTA) and locus coeruleus (LC). To assess the stability of these central catecholaminergic neurons following an acute episode of severe inflammation, 6 to 22 month-old C57/Bl6 mice received a maximally tolerated dose of LPS followed by euthanasia two hours later to assay peak levels of peripheral and central cytokines; and, 14 weeks later for computerized stereology of tyrosine hydroxylase-immunopositive (TH+) neurons in the SNPC-VTA and LC. Two hours after LPS, cytokine levels varied in an age-related manner, with the greatest peripheral and central elevations in old and young mice, respectively. Severe inflammation failed to cause loss of TH+ neurons in SNPC-VTA or LC; however, there was an age-related decline in these TH+ neurons in LPS-treated and control groups. Thus, unknown mechanisms in the B6 mouse brain appear to protect against catecholaminergic neuron loss during an acute episode of severe inflammation, while catecholaminergic neuron loss occurs during normal aging.
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影响因子：
2
作者：
Gundersen, HJG;Jensen, EBV;Nielsen, J
通讯作者：
Nielsen, J
影响因子：
3.8
作者：
CADET, JL;LAST, R;JACKSONLEWIS, V
通讯作者：
JACKSONLEWIS, V
DOI：
10.1016/s0165-3806(01)00315-7
发表时间：
2002-01-31
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Gayle, DA;Ling, ZD;Carvey, PM
通讯作者：
Carvey, PM
影响因子：
4.4
作者：
Gioannini, Theresa L.;Weiss, Jerrold P.
通讯作者：
Weiss, Jerrold P.
影响因子：
--
作者：
Aarsland, D;Andersen, K;Kragh-Sorensen, P
通讯作者：
Kragh-Sorensen, P