Absence of inflammatory lung injury in rabbits challenged intravascularly with complement-derived chemotactic factors.
Absence of inflammatory lung injury in rabbits challenged intravascularly with complement-derived chemotactic factors.
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用补体衍生的趋化因子进行血管内攻击的兔子没有出现炎症性肺损伤。
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
P. Henson
中科院分区：
文献类型：
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作者：
R. Webster;G. Larsen;B. Mitchell;A. Goins;P. Henson
补体系统的全身激活导致趋化因子的产生，这些因子被认为在炎症性肺部疾病（例如成人呼吸窘迫综合征）的发病机制中发挥作用。这让我们想知道眼镜蛇毒因子 (CVF) 或血管内给予酵母聚糖激活的兔血浆 (ZAP) 或兔 C5a 的全身补体激活是否会导致肺损伤。正如之前针对 CVF 和 ZAP 所描述的，静脉注射兔 C5a 也会引起急性中性粒细胞减少症以及肺血管系统内中性粒细胞的隔离。然而，通过中性粒细胞迁移或血管通透性增加来测量，三种刺激中的任何一种都没有发生明显的肺部炎症。只有当这些药物与麻醉、手术操作和插管相结合时，中性粒细胞才会显着迁移到肺泡中，但血管通透性却没有任何变化。给予 ZAP 后，出现动态顺应性下降、肺阻力增加以及短暂的低氧血症，而 CVF 或兔 C5a 治疗后未观察到这一情况。因此，我们的研究表明，ZAP 滴注后肺功能的变化可能并不代表单独补体激活的变化，因为它们不能用 CVF 或兔 C5a 重现。我们的结论是，补体激活作为一个孤立的事件，可能不足以对肺部造成严重的肺损伤。
Systemic activation of the complement system results in the generation of chemotactic factors that have been suggested to play a role in the pathogenesis of inflammatory pulmonary diseases such as the adult respiratory distress syndrome. This led us to ask whether systemic complement activation by cobra venom factor (CVF) or intravascularly administered zymosan-activated rabbit plasma (ZAP) or rabbit C5a would result in lung injury. As had been described previously for CVF and ZAP, intravenously administered rabbit C5a also caused an acute neutropenia along with sequestration of neutrophils within the pulmonary vasculature. However, no significant lung inflammation as measured by neutrophil emigration or increased vascular permeability occurred with any of the three stimuli. Only when these agents were combined with anesthesia, surgical manipulation, and intubation did significant neutrophil emigration into alveoli occur, but again without any change in vascular permeability. After administration of ZAP, a decrease in dynamic compliance and an increase in pulmonary resistance as well as a transient period of hypoxemia occurred that was not observed after CVF or rabbit C5a treatment. Thus, our studies suggest that changes in lung function after ZAP instillation may not represent changes from complement activation alone in that they are not reproduced with CVF or rabbit C5a. We conclude that complement activation, as an isolated event, may be an insufficient insult in the lung to produce significant lung injury.
人补体片段 C5a 和 C5ades Arg 对中性粒细胞功能的生物学影响。
DOI：
10.1016/0162-3109(80)90050-8
发表时间：
1980
期刊：
Immunopharmacology
影响因子：
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作者：
Webster,RO;Hong,SR;JohnstonJr,RB;Henson,PM
通讯作者：
Henson,PM