Inhibition of Cholesterol Biosynthesis by BM 15.766
Inhibition of Cholesterol Biosynthesis by BM 15.766
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BM 15.766 对胆固醇生物合成的抑制
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
F. H. Schmidt
中科院分区：
文献类型：
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作者：
J. Aufenanger;J. Pill;K. Stegmeier;F. H. Schmidt
BM 15.766 (4-[2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]benzoic acid) showed a dose dependent action on 14C-acetate incorporation in cholesterol and intermediates including squalene by adult rat hepatocytes in primary monolayer culture. The biosynthesis of cholesterol could be reduced by more than 90%. Simultaneously, the 7-dehydrocholesterol level rose in the cells and, to a less marked extent, in the culture medium.
