VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
复制标题
DOI：
10.1200/jco.2007.13.5947
复制
发表时间：
2008-02-20
影响因子：
45.3
通讯作者：
Christiani, David C.
中科院分区：
文献类型：
--
作者：
Heist, Rebecca Suk;Zhai, Rihong;Christiani, David C.
目的VEGF基因的多态性被认为具有功能活性。我们假设这种多态性可能影响早期非小细胞肺癌（NSCLC）患者的生存结果。我们评估了1992年至2001年在马萨诸塞州总医院接受手术切除的早期非小细胞肺癌患者中VEGF多态性与总生存率（OS）的关系。我们专门研究了VEGF多态性+936C>T （rs3025039）、-460T>C （rs833061）和+405G>C （rs2010963）。采用Cox比例风险模型、Kaplan-Meier方法和log-rank检验分析基因型与生存结果的相关性。结果共收治462例患者，死亡237例。携带VEGF +405G>C多态性变异C等位基因的患者生存率显著提高（粗风险比[HR] = 0.70; 95% CI, 0.54 ~ 0.90； P= 0.006；调整后HR = 0.70; 95% CI, 0.54 ~ 0.91； P= 0.008）。携带VEGF +405G>C多态性变异C等位基因的患者的5年生存率为61% (95% CI， 54%至67%)，而携带野生型变异的患者为51% （95% CI， 43%至59%）。携带VEGF +936C>T多态性变异T等位基因的患者有提高生存率的趋势（粗HR = 0.74; 95% CI, 0.53 ~ 1.03； P= 0.07；调整HR = 0.73; 95% CI, 0.52 ~ 1.03； P= 0.07）。此外，+405G>C和+936C>T多态性等位基因数量较多的患者生存率更高。未发现与- 460t> C多态性相关。结论VEGF基因多态性可能影响早期肺癌患者的生存。
Purpose Polymorphisms in the VEGF gene have been identified that are believed to have functional activity. We hypothesized that such polymorphisms may affect survival outcomes among early-stage non-small-cell lung cancer (NSCLC) patients.Patients and Methods We evaluated the relationship between VEGF polymorphisms and overall survival (OS) among patients with early-stage NSCLC treated with surgical resection at Massachusetts General Hospital from 1992 to 2001. We specifically investigated the VEGF polymorphisms +936C>T (rs3025039), -460T>C (rs833061), and +405G>C (rs2010963). Analyses of genotype associations with survival outcomes were performed using Cox proportional hazards models, Kaplan-Meier methods, and the log-rank test.Results There were 462 patients and 237 deaths. Patients carrying the variant C allele of the VEGF +405G>C polymorphism had significantly improved survival (crude hazard ratio [HR] = 0.70; 95% CI, 0.54 to 0.90; P=.006; adjusted HR = 0.70; 95% CI, 0.54 to 0.91; P=.008). Five-year OS for patients carrying the variant C allele of the VEGF +405G>C polymorphism was 61% (95% CI, 54% to 67%) versus 51% (95% CI, 43% to 59%) for those who had the wild-type variant. There was a trend toward improved survival among patients carrying the variant T allele of the VEGF +936C>T polymorphism (crude HR = 0.74; 95% CI, 0.53 to 1.03; P=.07; adjusted HR = 0.73; 95% CI, 0.52 to 1.03; P=.07). Moreover, patients with higher number of variant alleles of the +405G>C and +936C>T polymorphisms had better survival. There was no association found with the -460T>C polymorphism.Conclusion Polymorphisms in VEGF may affect survival in early-stage lung cancer.