Fitting the linear-quadratic model to detailed data sets for different dose ranges
Fitting the linear-quadratic model to detailed data sets for different dose ranges
复制标题
DOI：
10.1088/0031-9155/51/11/009
复制
发表时间：
2006-06-07
影响因子：
3.5
通讯作者：
Raaphorst, G. P.
中科院分区：
文献类型：
--
作者：
Garcia, L. M.;Leblanc, J.;Raaphorst, G. P.
分析了高剂量率的广泛剂量范围内的生存曲线行为以及线性二次（LQ）模型与实验数据之间的对应程度。进行了详细的克隆形成试验，辐射增量为 0.5 Gy，总剂量范围为 10.5 至 16 Gy。研究的细胞系为：CHOAA8（中国仓鼠成纤维细胞）、U373MG（人胶质母细胞瘤细胞）、CP3和DU145（人前列腺癌细胞系）。分析基于2- 统计数据和实验的蒙特卡罗模拟。观察到极低剂量 (< 2 Gy) 时 LQ 拟合质量下降。这一结果可以通过 CHOAA8、U373MG 和 DU145 数据中观察到的超敏效应以及 CP3 细胞系中的适应性反应来解释。通过删除低剂量数据点可以看出拟合度的明显改善。高剂量时拟合度恶化也表明 LQ 无法解释该区域。这表明 LQ 模型更适合生存曲线的中间剂量区域。我们的研究中进行的分析揭示了不同细胞系中 LQ 拟合的剂量依赖性。
Survival curve behaviour and degree of correspondence between the linear quadratic (LQ) model and experimental data in an extensive dose range for high dose rates were analysed. Detailed clonogenic assays with irradiation given in 0.5 Gy increments and a total dose range varying from 10.5 to 16 Gy were performed. The cell lines investigated were: CHOAA8 (Chinese hamster fibroblast cells), U373MG (human glioblastoma cells), CP3 and DU145 (human prostate carcinoma cell lines). The analyses were based on.2- statistics and Monte Carlo simulation of the experiments. A decline of LQ fit quality at very low doses (< 2 Gy) is observed. This result can be explained by the hypersensitive effect observed in CHOAA8, U373MG and DU145 data and an adaptive-type response in the CP3 cell line. A clear improvement of the fit is discerned by removing the low dose data points. The fit worsening at high doses also shows that LQ cannot explain this region. This shows that the LQ model fits better the middle dose region of the survival curve. The analysis conducted in our study reveals a dose dependency of the LQ fit in different cell lines.