How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.
How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.
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DOI：
10.1002/cpt.2354
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发表时间：
2021-09
影响因子：
6.7
通讯作者：
Wiisanen K
中科院分区：
文献类型：
--
作者：
Cicali EJ;Elchynski AL;Cook KJ;Houder JT;Thomas CD;Smith DM;Elsey A;Johnson JA;Cavallari LH;Wiisanen K
CYP2D6基因正越来越多地被整合到实践中，以指导某些药物的处方。药物代谢酶对药物的抑制很敏感，这可能导致临床表型不同于基于基因的表型，这一过程被称为表型转化。表观转化非常普遍，但没有广泛地融入实践，原因要么是关于如何整合的经验有限，要么是缺乏对它发生的了解。我们建立了一个计算器工具，帮助临床医生将评估CYP2D6表型转化的标准化方法整合到实践中。在建立工具的过程中，我们确定了在将CYP2D6表型转化应用于临床实践时需要考虑的几个临床因素。本教程分享了佛罗里达大学健康精密医学项目在构建计算器工具时所采取的步骤，并确定了在临床实践中实施CYP2D6表型转换时需要考虑的临床因素。
CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of either limited experience on how to integrate or lack of knowledge that it has occurred. We built a calculator tool to help clinicians integrate a standardized method of assessing CYP2D6 phenoconversion into practice. During tool-building, we identified several clinical factors that need to be considered when implementing CYP2D6 phenoconversion into clinical practice. This tutorial shares the steps that the University of Florida Health Precision Medicine Program took to build the calculator tool and identified clinical factors to consider when implementing CYP2D6 phenoconversion in clinical practice.
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影响因子：
6.7
作者：
Crews KR;Monte AA;Huddart R;Caudle KE;Kharasch ED;Gaedigk A;Dunnenberger HM;Leeder JS;Callaghan JT;Samer CF;Klein TE;Haidar CE;Van Driest SL;Ruano G;Sangkuhl K;Cavallari LH;Müller DJ;Prows CA;Nagy M;Somogyi AA;Skaar TC
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Skaar TC
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影响因子：
1.9
作者：
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影响因子：
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影响因子：
6.7
作者：
Crews, K. R.;Gaedigk, A.;Skaar, T. C.
通讯作者：
Skaar, T. C.