The clinical significance of tumor-associated antigen RCAS1 expression in the normal, hyperplastic, and malignant uterine endometrium
The clinical significance of tumor-associated antigen RCAS1 expression in the normal, hyperplastic, and malignant uterine endometrium
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DOI：
10.1006/gyno.2000.5981
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发表时间：
2000-12-01
影响因子：
4.7
通讯作者：
Nakano, H
中科院分区：
文献类型：
--
作者：
Sonoda, K;Kaku, T;Nakano, H
Objective.肿瘤相关抗原RCAS 1被22-1-1单克隆抗体识别。它被发现在来自子宫和卵巢的癌中，尤其是在浸润性癌中强烈表达。先前的研究表明RCAS 1表达与宫颈腺癌的不良预后相关。本研究旨在探讨RCAS 1的表达是否与子宫内膜肿瘤的进展有关。RCAS 1的表达通过免疫组织化学分析来评估。本研究所用的组织标本包括46例正常子宫内膜，40例增生性子宫内膜，121例腺癌。RCAS 1的表达与子宫内膜腺癌的临床病理变量（临床分期、组织学、分级、肌层浸润、淋巴管浸润和淋巴结转移）之间的关系也进行了评估。RCAS 1在正常子宫内膜标本中的阳性率为26%（12/46例），在增生标本中的阳性率为32%（13/40例），在腺癌标本中的阳性率为68%（83/121例）。结果表明，RCAS 1在子宫内膜腺癌中的表达明显高于正常子宫内膜和增生子宫内膜（P < 0.0001）。RCAS 1在3级子宫内膜癌中的表达明显高于1级和2级子宫内膜癌（P <0. 05），但其表达与子宫内膜癌的临床分期、肌层浸润、淋巴管浸润、淋巴结转移无关。因此，RCAS 1表达可能与子宫内膜腺癌的恶性转化和低分化有关。(C)北京大学出版社.
Objective. A tumor-associated antigen, RCAS1, is recognized by 22-1-1 monoclonal antibody. It was found in carcinomas derived from the uterus and ovary and was especially strongly expressed in invasive cancers. A previous investigation showed the RCAS1 expression to be correlated with a poor prognosis in uterine cervical adenocarcinoma. In this study, we examined whether the expression of RCAS1 is associated with the progression of the uterine endometrial neoplasms.Methods. The expression of RCAS1 was evaluated by an immunohistochemical analysis. The tissue specimens used in this study included 46 cases of normal uterine endometrium, 40 cases of hyperplasia, and 121 cases of adenocarcinoma. The relationship between RCAS1 expression and several clinicopathological variables (clinical stage, histology, grade, myometrial invasion, lymph-vascular space invasion, and lymph node metastasis) was also assessed in endometrial adenocarcinoma.Results. RCAS1 was positive in 26% of the normal uterine endometrium specimens (12 of 46 total cases), in 32% of the hyperplasia specimens (13 of 40 total cases), and in 68% of the adenocarcinoma specimens (83 of 121 total cases). As a result, the expression of RCAS1 was statistically higher in adenocarcinoma than in the normal and hyperplastic endometrium (P < 0.0001). RCAS1 was statistically detected more frequently in grade 3 than in grade 1 or 2 (P < 0.05); however, there was no correlation between the antigen expression and the clinical stage, myometrial invasion, lymph-vascular space invasion, or lymph node metastasis.Conclusion. RCAS1 expression might thus be associated with the malignant transformation and poor differentiation observed in uterine endometrial adenocarcinoma. (C) 2000 Academic Press.