Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population
Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population
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维生素D受体的遗传变异与中国人群丙型肝炎病毒感染的结果相关
DOI：
10.1038/jhg.2015.117
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发表时间：
2016
影响因子：
3.5
通讯作者：
Yue Ming
中科院分区：
文献类型：
--
作者：
Wu Meng-ping;Zhang Jin-wei;Huang Peng;Han Ya-ping;Zhang Yun;Peng Zhi-hang;Wang Jie;Zhu Ping;Su Jing;Yu Rong-bin;Li Jun;Yue Ming
维生素D被认为是一种免疫调节剂，并通过维生素D受体（VDR）发挥作用。本研究探讨VDR基因单核苷酸多态性（SNPs）与丙型肝炎病毒（HCV）感染结局的关系。采用TaqMan技术对538例HCV自然清除者、834例持续感染者和1030例未感染者的rs 2228570、rs757343和rs739837三个SNP位点进行基因分型。二元逻辑分析用于控制混杂因素的影响。结果表明，携带rs757343 A和rs739837 A等位基因的人群，其HCV易感性显著降低（P < 0.05）。在分层分析中，rs757343 A等位基因和rs739837 A等位基因对HCV感染的保护在某些亚组中仍然有效。此外，携带rs739837 CA基因型的患者不易发生持续感染（P Bonferroni= 0.033），分层分析中，这种效应在多个亚组中仍然有效。单倍型分析表明，与最常见的GC单倍型相比，携带AA（OR = 0.66，95%CI = 0.56-0.78）和GA（OR= 0.64，95%CI = 0.47-0.85）的单倍型具有保护作用。我们的研究结果表明，VDR基因多态性与中国人群中HCV感染的结局有关。
Vitamin D has been considered as an immune modulator, and exerted the effect through the vitamin D receptor (VDR). This study investigated the associations of single-nucleotide polymorphisms (SNPs) of VDR with the outcomes of Hepatitis C virus (HCV) infection. Three SNPs (rs2228570, rs757343 and rs739837) were genotyped by TaqMan assay among Chinese population, including 538 HCV spontaneous clearance subjects, 834 persistent infection subjects and 1030 uninfected subjects. Binary logistic analyses were used to control the effects of confounding factors. The results showed that subjects with the rs757343 A allele and rs739837 A allele had the significantly reduced risk of HCV susceptibility (all P Bonferroni< 0.05 in dominant/additive model). In the stratified analysis, the protection of rs757343 A allele and rs739837 A allele against HCV infection remained effective in some subgroups. In addition, patients carrying rs739837 CA genotype were less prone to develop persistent infection (P Bonferroni= 0.033) and such effect still work in several subgroups in the stratified analysis. Furthermore, haplotype analysis indicated that when compared with the most frequent GC haplotype, the haplotype carrying AA (odds ratio (OR)= 0.66, 95% confidence interval (CI)= 0.56–0.78) and GA (OR= 0.64, 95% CI= 0.47–0.85) suggested a protective effect. Our findings indicated that the polymorphisms of VDR are associated with the outcomes of HCV infection among Chinese population.