Pregnancy suppresses experimental autoimmune encephalomyelitis through immunoregulatory cytokine production
Pregnancy suppresses experimental autoimmune encephalomyelitis through immunoregulatory cytokine production
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DOI：
10.4049/jimmunol.179.12.8146
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发表时间：
2007-12-15
影响因子：
4.4
通讯作者：
Whitacre, Caroline C.
中科院分区：
文献类型：
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作者：
McClain, Melanie A.;Gatson, NaTosha N.;Whitacre, Caroline C.
患有多发性硬化症（MS）的妇女通常在怀孕期间复发率下降，最明显的是在妊娠晚期，产后3-6个月出现疾病活动的爆发。实验性自身免疫性脑脊髓炎（EAE）是多发性硬化症的动物模型，研究表明，怀孕可以延缓发病并降低发病率。我们研究了妊娠期和产后对小鼠EAE发作-复发模型的影响。在妊娠期进行免疫接种，小鼠EAE发病率降低，临床严重程度降低，而在产后进行免疫接种的小鼠病情更为严重。与未怀孕的对照组相比，在怀孕期间进行免疫接种时，淋巴细胞增殖或激活标记物的表达没有差异。在怀孕期间免疫的小鼠产生较少的tnf - α和IL-17，并且在CD11b(+), CD11c(+), CD19（+）和CD4(+)/CD25（+）群体中显示出更多的il -10分泌细胞。在ifn - γ、IL-2、IL-4和IL-5的产生上没有发现差异。这些结果表明，当在妊娠期间引入Ag时，免疫调节而不是免疫抑制或Th2环境占主导地位。
Women with multiple sclerosis (MS) often experience a decrease in relapse rate during pregnancy, most notably during the third trimester, with a flare of disease activity 3-6 mo postpartum. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have shown that pregnancy delays the onset and decreases the incidence of disease. We investigated the effect of pregnancy and the postpartum period in a remitting-relapsing model of murine EAE. When immunization occurs during pregnancy, mice show a reduction in the incidence of EAE as well as a decrease in clinical severity, while mice immunized during the postpartum period exhibit more severe disease. No differences in lymphocyte proliferation or expression of activation markers were noted when immunization occurred during pregnancy as compared with the nonpregnant controls. Mice immunized during pregnancy produced less TNF-alpha and IL-17, and showed an increased number of IL-10-secreting cells within the CD11b(+), CD11c(+), CD19(+), and CD4(+)/CD25(+) populations. No differences were noted in the production of IFN-gamma, IL-2, IL-4, and IL-5. These results suggest that when an Ag is introduced during pregnancy, an immunoregulatory rather than an immunosuppressive or Th2 environment predominates.