The CCAAT-binding complex (CBC) in Aspergillus species
The CCAAT-binding complex (CBC) in Aspergillus species
复制标题
DOI：
10.1016/j.bbagrm.2016.11.008
复制
发表时间：
2017-05-01
影响因子：
4.7
通讯作者：
Brakhage, Axel A.
中科院分区：
文献类型：
--
作者：
Hortschansky, Peter;Haas, Hubertus;Brakhage, Axel A.
背景资料：CCAAT结合复合物（CBC），由一个异源三聚体的核心结构，是高度保守的真核生物，并构成一个重要的一般转录regulator.Scope的审查。在这篇综述中，我们讨论了科学的历史和目前的知识状态的多个基因调控功能，蛋白质基序和结构的CBC在真菌中，特别侧重于曲霉属物种。主要结论和一般意义：最初确定为一个转录激活呼吸在酿酒酵母，在其他真菌物种的CBC被发现参与了高度多样化的途径，但其参与的一般原理是失踪。随后，发现CBC通过半胱氨酸残基的氧化修饰来感测活性氧，以介导氧化还原调节。此外，通过与铁敏感bZIP转录因子HapX的相互作用，CBC被证明介导适应铁饥饿和铁过量。由于控制着初级和次级代谢中的各种途径，CBC对于动植物宿主中的真菌毒力以及抗真菌抗性至关重要。因此，CBC介导的控制影响生物技术，农业和感染医学高度关注的生物过程。这篇文章是特刊的一部分，题为：核因子Y在发展和疾病中，由Roberto Mantovani教授编辑。(C)2016爱思唯尔B.V.保留所有权利。
Background: The CCAAT binding complex (CBC), consisting of a heterotrimeric core structure, is highly conserved in eukaryotes and constitutes an important general transcriptional regulator.Scope of the review.In this review we discuss the scientific history and the current state of knowledge of the multiple gene regulatory functions, protein motifs and structure of the CBC in fungi with a special focus on Aspergillus species. Major conclusions and general significance.Initially identified as a transcriptional activator of respiration in Saccharomyces cerevisiae, in other fungal species the CBC was found to be involved in highly diverse pathways, but a general rationale for its involvement was missing. Subsequently, the CBC was found to sense reactive oxygen species through oxidative modifications of cysteine residues in order to mediate redox regulation. Moreover, via interaction with the iron-sensing bZIP transcription factor HapX, the CBC was shown to mediate adaptation to both iron starvation and iron excess. Due to the control of various pathways in primary and secondary metabolism the CBC is of crucial importance for fungal virulence in both animal and plant hosts as well as antifungal resistance. Consequently, CBC-mediated control affects biological processes that are of high interest in biotechnology, agriculture and infection medicine. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani. (C) 2016 Elsevier B.V. All rights reserved.