Associations of fat and muscle masses with bone mineral in elderly men and women
Associations of fat and muscle masses with bone mineral in elderly men and women
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DOI：
10.1093/ajcn/63.3.365
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发表时间：
1996-03-01
影响因子：
7.1
通讯作者：
Garry, PJ
中科院分区：
文献类型：
--
作者：
Baumgartner, RN;Stauber, PM;Garry, PJ
对301名年龄大于或等于65岁的男性和女性的脂肪和肌肉质量与骨矿物质状况的关系进行了研究。用双能X射线吸收法估计了骨矿物质和软组织成分。单变量相关性表明，在男性中，肌肉比脂肪与骨矿物质含量(BMC)以及骨矿物质密度(BMD)更密切相关。然而，在女性中，BMC与肌肉的相关性仅略高于与脂肪的相关性，而与BMD的相关性始终是与脂肪的相关性大于与肌肉的相关性。这表明BMC与肌肉的相关性受骨骼和身体大小的影响，尤其是在女性。建立了一个多元回归模型，根据骨面积、膝关节高度、年龄以及脂肪和肌肉的独立作用调整BMC。在男性中，肌肉与调整后的BMC的关系比与脂肪的关系更密切。在女性中，脂肪质量与BMC显著相关，但肌肉质量与BMC无关。服用雌激素的女性是个例外，她们的脂肪和肌肉与调整后的BMC都没有明显的关联。这项研究表明，在不服用雌激素的老年女性中，身体脂肪可能比肌肉更重要，以保持骨矿物质。
Associations of fat and muscle masses with bone mineral status were studied in 301 men and women aged greater than or equal to 65 y. Bone mineral and soft tissue composition were estimated by using dual-energy X-ray absorptiometry. Univariate correlations suggested that muscle is associated more closely than fat with bone mineral content (BMC) as well as with bone mineral density (BMD) in men. In women, however, correlations of BMC with muscle were only slightly greater than those with fat and correlations with BMD were consistently, greater with fat than with muscle. This suggests that correlations of BMC with muscle are influenced by bone and body size, especially in women. A multiple-regression model was developed that adjusts BMC for bone area, knee height, age, and the independent effects of fat and muscle. In men, muscle remained more closely associated with adjusted BMC than with fat. In women, fat mass was associated significantly with BMC but muscle mass was not. The exception was for women taking estrogen, in whom neither fat nor muscle was associated significantly with adjusted BMC. This study suggests that body fatness may be more important than muscle in maintaining bone mineral in elderly women not taking estrogen.