New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans.
New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans.
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DOI：
10.1021/acschembio.6b00398
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发表时间：
2016-08-19
影响因子：
4
通讯作者：
Kelleher, Neil L.
中科院分区：
文献类型：
--
作者：
Henke, Matthew T.;Soukup, Alexandra A.;Goering, Anthony W.;McClure, Ryan A.;Thomson, Regan J.;Keller, Nancy P.;Kelleher, Neil L.
解锁真菌的生化储存是开发未来药物的关键。通过降低构巢曲霉中关键组蛋白脱乙酰酶的表达，观察到15种新的曲霉隐菌素水平增加了100倍，这些曲霉隐菌素是最近描述的具有两种来自辛酸和十二烷酸的非典型氨基酸的脂肽。除了两个NMR验证的结构，MS/MS网络帮助发现了另外13个aspercryptins。曲霉素打破了脂肽的常规结构取向，并且与已知的这类化合物相比显得“落后”。我们还证实了14个基因的aspercryptin生物合成基因簇，该基因簇编码两种脂肪酸脱氢酶和几种将饱和辛酸和十二烷酸转化为α-氨基酸的酶。
Unlocking the biochemical stores of fungi is key for developing future pharmaceuticals. Through reduced expression of a critical histone deacetylase in Aspergillus nidulans, increases of up to 100-fold were observed in the levels of 15 new aspercryptins, recently described lipopeptides with two non-canonical amino acids derived from octanoic and dodecanoic acids. In addition to two NMR-verified structures, MS/MS networking helped uncover an additional 13 aspercryptins. The aspercryptins break the conventional structural orientation of lipopeptides and appear “backward” when compared to known compounds of this class. We have also confirmed the 14-gene aspercryptin biosynthetic gene cluster, which encodes two fatty acid synthases and several enzymes to convert saturated octanoic and dodecanoic acid to α-amino acids.
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影响因子：
3.7
作者：
Niehaus, Eva-Maria;Janevska, Slavica;Tudzynski, Bettina
通讯作者：
Tudzynski, Bettina
DOI：
10.1007/s10295-005-0077-9
发表时间：
2006-07-01
影响因子：
3.4
作者：
Baltz, Richard H.
通讯作者：
Baltz, Richard H.
DOI：
10.1099/00221287-145-12-3539
发表时间：
1999-12-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Cheng, YQ;Ahn, JH;Walton, JD
通讯作者：
Walton, JD
影响因子：
3.6
作者：
Miller, Eric D.;Kauffman, Christopher A.;Fenical, William
通讯作者：
Fenical, William
影响因子：
2.9
作者：
Offenzeller, M;Santer, G;SchneiderScherzer, E
通讯作者：
SchneiderScherzer, E