Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis.
Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis.
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在器官发生过程中，大部分内脏间皮是由常驻祖细胞（而非外源性迁移细胞）产生的。
DOI：
10.1016/j.ydbio.2014.04.003
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发表时间：
2014
影响因子：
2.7
通讯作者：
Bader,DavidM
中科院分区：
文献类型：
--
作者：
Winters,NichelleI;Williams,AnnabelleM;Bader,DavidM
从历史上看，对间皮细胞分化的分析主要集中在心脏，来自局部“外在”来源的高度迁移的祖细胞群体移动到发育中的器官并越过发育中的器官。这一模型长期以来一直是这种细胞类型生成的范例。在这里，使用鸡/鹌鹑嵌合移植和随后的间皮细胞种群鉴定，我们证明了在脊椎动物器官发生中存在着不同的间皮产生机制。在这个新发现的模型中，间皮祖细胞是发育中的消化系统和呼吸系统器官的固有细胞。此外，我们证明了早期心脏在发育过程中能够招募一个完全外源性的间皮细胞层。因此，新发现的间皮形成的“器官固有”模型似乎占主导地位，而长期研究的间皮发育的心脏模型可能是异常值。
Historically, analyses of mesothelial differentiation have focused on the heart where a highly migratory population of progenitors originating from a localized “extrinsic” source moves to and over the developing organ. This model long stood alone as the paradigm for generation of this cell type. Here, using chick/quail chimeric grafting and subsequent identification of mesothelial cell populations, we demonstrate that a different mechanism for the generation of mesothelia exists in vertebrate organogenesis. In this newly discovered model, mesothelial progenitors are intrinsic to organs of the developing digestive and respiratory systems. Additionally, we demonstrate that the early heart stands alone in its ability to recruit an entirely exogenous mesothelial cell layer during development. Thus, the newly identified “organ intrinsic” model of mesotheliogenesis appears to predominate while the long-studied cardiac model of mesothelial development may be the outlier.