Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study
Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study
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DOI：
10.1017/s003329171300319x
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发表时间：
2014-09-01
影响因子：
6.9
通讯作者：
Li, T.
中科院分区：
文献类型：
--
作者：
Chen, Z.;Deng, W.;Li, T.
背景灰质（GM）的改变在精神分裂症中常见。越来越多的研究表明，与精神分裂症相关的大脑变化是分布式的，而不是局部的，涉及相互连接的区域网络，而不是单个区域。在本研究中，我们的目的是探讨GM体积（GMV）的变化，在一个相对较大的样本的治疗初发精神分裂症（FES）患者使用优化的基于体素的形态测量（VBM）和协变分析。使用3.0 T磁共振成像（MRI）从86名首次发作的药物初治精神分裂症患者和86名年龄和性别匹配的健康志愿者中获得高分辨率T1加权图像。采用阳性和阴性症状量表（PANSS）评估症状严重程度。使用优化的VBM和16个感兴趣区域（ROI）评估GMV，这些区域是根据先前的荟萃分析选择的。使用协方差分析（ANCOVA）检查ROI中GMV之间的关系。VBM分析显示，首次发作患者双侧海马GMV降低。ROI分析确定了左侧额下回、双侧海马和右侧丘脑的GMV减少。ANCOVA揭示了患者和对照组局部GMV相关性的不同模式，包括岛叶间和岛叶内、杏仁核间和岛叶-中央后回连接。结论。精神分裂症涉及GMV的区域性减少和GMV协方差在杏仁核，杏仁核和中央后回的变化。这些发现在疾病发作时、治疗前很明显，因此不能归因于慢性疾病进展或药物治疗的影响。
Background. Alterations in gray matter (GM) are commonly observed in schizophrenia. Accumulating studies suggest that the brain changes associated with schizophrenia are distributed rather than focal, involving interconnected networks of areas as opposed to single regions. In the current study we aimed to explore GM volume (GMV) changes in a relatively large sample of treatment-naive first-episode schizophrenia (FES) patients using optimized voxel-based morphometry (VBM) and covariation analysis.Method. High-resolution T1-weighted images were obtained using 3.0-T magnetic resonance imaging (MRI) from 86 first-episode drug-naive patients with schizophrenia and 86 age- and gender-matched healthy volunteers. Symptom severity was evaluated using the Positive and Negative Syndrome Scale (PANSS). GMV was assessed using optimized VBM and in 16 regions of interest (ROIs), selected on the basis of a previous meta-analysis. The relationships between GMVs in the ROIs were examined using an analysis of covariance (ANCOVA).Results. The VBM analysis revealed that first-episode patients showed reduced GMV in the hippocampus bilaterally. The ROI analysis identified reductions in GMV in the left inferior frontal gyrus, bilateral hippocampus and right thalamus. The ANCOVA revealed different patterns of regional GMV correlations in patients and controls, including of interand intra-insula, inter-amygdala and insula-postcentral gyrus connections.Conclusions. Schizophrenia involves regional reductions in GMV and changes in GMV covariance in the insula, amygdala and postcentral gyrus. These findings were evident at the onset of the disorder, before treatment, and therefore cannot be attributable to the effects of chronic illness progression or medication.