INHIBITION OF HIV-1 INFECTION BY A FUSION DOMAIN BINDING PEPTIDE FROM THE HIV-1 ENVELOPE GLYCOPROTEIN-GP41
INHIBITION OF HIV-1 INFECTION BY A FUSION DOMAIN BINDING PEPTIDE FROM THE HIV-1 ENVELOPE GLYCOPROTEIN-GP41
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DOI：
10.1006/bbrc.1993.2078
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发表时间：
1993-09-15
影响因子：
3.1
通讯作者：
NEURATH, AR
中科院分区：
文献类型：
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作者：
JIANG, SB;LIN, K;NEURATH, AR
与HIV-1糖蛋白gp41序列（637-666）对应的合成肽抑制了一系列HIV-1菌株的复制。该肽（637-666）选择性地结合gp41的n端融合域，表明抑制HIV-1感染是通过阻断HIV-1与细胞或感染细胞与未感染细胞的融合引起的。由于该肽对同源和异源HIV-1分离株都具有抗病毒活性，并且没有可检测到的细胞毒性，因此它为艾滋病的化疗和预防提供了一种新的途径。
A synthetic peptide, corresponding to the sequence (637-666) of the HIV-1 glycoprotein gp41, inhibited the replication of an array of HIV-1 strains. The peptide (637-666) selectively binds to the fusion domain at the N-terminus of gp41, suggesting that inhibition of HIV-1 infection is caused by blocking fusion of HIV-1 with cells or of infected cells with uninfected cells. Since this peptide has antiviral activity against both homologous and heterologous HIV-1 isolates and has no detectable cytotoxicity, it offers a novel approach to chemotherapy and prophylaxis of AIDS.