Patterned surfaces with the controllable drug doses using inkjet printing
Patterned surfaces with the controllable drug doses using inkjet printing
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DOI：
10.1557/s43578-021-00135-3
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发表时间：
2021-03-04
影响因子：
2.7
通讯作者：
Narayan, Roger J.
中科院分区：
文献类型：
--
作者：
Azizi Machekposhti, Sina;Zhang, Bin;Narayan, Roger J.
在烧伤和创伤创面中发现了包括金黄色葡萄球菌、铜绿假单胞菌和白色念珠菌在内的微生物群的混合物。本研究采用压电喷墨打印技术，将抗真菌药两性霉素B和抗菌剂阿奇霉素分别应用于纱布、硅和铝的表面。在未修饰、二甲基亚砜载体修饰、阿奇霉素修饰和两性霉素B修饰的表面上进行了体外纸片扩散试验。与未修饰和二甲基亚砜载体修饰的表面不同，两性霉素B修饰的表面对白色念珠菌具有抗真菌活性；阿奇霉素修饰的表面对金黄色葡萄球菌和铜绿假单胞菌具有抗菌活性。二甲基亚砜载体修饰的表面没有显示出对金黄色葡萄球菌、铜绿假单胞菌或白色念珠菌的活性。结果表明，压电喷墨打印技术可用于在纱布中同时装载水溶性较差的抗菌药物和抗真菌药物用于混合创面的治疗。
A mixture of microflora, including Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, is found in burns and traumatic wounds. In this study, piezoelectric inkjet printing was used to apply an antifungal agent, amphotericin B, and an antibacterial agent, azithromycin, to the surfaces of gauze, silicon, and aluminum. The in vitro disk diffusion assay was performed on the unmodified, dimethyl sulfoxide vehicle-modified, azithromycin-modified, and amphotericin B-modified surfaces. Unlike the unmodified and dimethyl sulfoxide vehicle-modified surfaces, the amphotericin B-modified surfaces showed antifungal activity against C. albicans; the azithromycin-modified surfaces showed antibacterial activity against Staphylococcus aureus and P. aeruginosa. The dimethyl sulfoxide vehicle-modified surface did not show activity against S. aureus, P. aeruginosa, or C. albicans. The results indicate that piezoelectric inkjet printing may be useful for loading gauze with both antibacterial and antifungal pharmacologic agents with poor solubility in aqueous solutions for the treatment of mixed wounds.