Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder - Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study).
Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder - Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study).
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DOI：
10.3389/fpsyt.2016.00150
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发表时间：
2016
影响因子：
4.7
通讯作者：
Air T
中科院分区：
文献类型：
--
作者：
Baune BT;Air T
研究重度抑郁症的临床、功能和生物学相关性的横断面和纵向研究非常频繁。在这种类型的研究中，抑郁症通常被定义为基于使用诊断工具的研究的分类诊断。鉴于抑郁症的表型和生物学异质性，我们选择将表型评估集中在抑郁症的三个认知维度上，包括(a)认知表现，(b)情绪处理和(c)社会认知功能。因此，本研究的总体目的是调查抑郁症患者这些认知维度的长期临床过程及其功能（社会心理）相关因素。我们还旨在确定抑郁症这三个认知维度的生物学“基因组”相关性。为了实现上述总体目标，我们创建了认知和情绪研究（CoFaMS），其主要目的是通过采用前瞻性研究设计并纳入健康对照组，研究抑郁症认知维度的临床、功能和生物学相关性。该研究于2015年4月开始，包括根据DSM-IV-TR标准初步诊断为重度抑郁症或双相情感障碍的重度抑郁发作的患者。评估内容包括抑郁症的三个认知维度（认知表现、情绪处理和社会认知）、认知功能筛查工具、评估一般功能、工作场所功能和社会心理功能的功能量表、抑郁症状量表和临床病程。收集血液是为了对抑郁症认知维度的生物学相关性进行全面的基因组发现分析。cofam研究代表了一种创新的方法，专注于抑郁症的认知维度及其功能和生物“基因组”相关性。CoFaMS团队欢迎与国内和国际研究人员合作。
Cross-sectional and longitudinal studies exploring clinical, functional, and biological correlates of major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including (a) cognitive performance, (b) emotion processing, and (c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological “genomic” correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional, and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015, including patients with a primary diagnosis of a major depressive episode of major depressive disorder or bipolar disorder according to DSM-IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, and social cognition), cognitive function screening instrument, plus functional scales to assess general, work place, and psychosocial function, depression symptom scales, and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focusing on cognitive dimensions of depression and its functional and biological “genomic” correlates. The CoFaMS team welcomes collaborations with both national and international researchers.