Preparing molecularly imprinted membranes by phase inversion to separate kaempferol
Preparing molecularly imprinted membranes by phase inversion to separate kaempferol
复制标题
相转化制备分子印迹膜分离山奈酚
DOI：
10.1002/pat.3898
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发表时间：
2017
影响因子：
3.4
通讯作者：
Yun Yanbin
中科院分区：
文献类型：
--
作者：
Huang Zejun;Zhang Pin;Yun Yanbin
研究了分子印迹膜(MIMs)对山奈酚这一重要活性药物成分的分离作用。采用液-固相转化法制备了山奈酚分子印迹聚合物。研究了聚苯砜、氯化锂和氯化锌对膜性能的影响，制备了高通量分子印迹聚合物膜，并制备了山奈酚分子印迹聚合物膜、非分子印迹聚合物膜和非分子印迹聚合物膜，考察了膜的吸附性能。从吸附等温线看，最大平衡吸附量为890MIM/g，为 。分子印迹聚合物膜和分子印迹聚合物膜对山奈酚具有较高的选择性；非分子印迹聚合物膜和非分子印迹聚合物膜对山奈酚的吸附量和选择性较低。MIM的重用实验表明，它具有良好的可重用性。结果表明，结合部位在MIMS的分离过程中起着重要作用。版权所有©2016 John Wiley&Sons，Ltd.
Molecularly imprinted membranes (MIMs) were studied to separate special target molecule – kaempferol, an important active pharmaceutical ingredient. The kaempferol MIM were prepared by the liquid–solid phase inversion method. The effects of polyphenylene sulfone, LiCl, and ZnCl2on membrane performance were studied, a high Flux MIM was prepared, then the kaempferol molecularly imprinted polymer membrane, non‐molecularly imprinted membrane, and non‐molecularly imprinted polymer membrane were prepared to investigate adsorption capacity. From adsorption isotherm curve, the maximum equilibrium adsorption quantity was 890 µg/g, and it was MIM. The MIM and molecularly imprinted polymer membrane give high selectivity towards kaempferol; the non‐molecularly imprinted membrane and non‐molecularly imprinted polymer membrane showed low adsorption quantity and selectivity. The reuse experiment of the MIM indicated that it has good reuse property. All the results showed binding sites were important in the separation process of MIMs. Copyright © 2016 John Wiley & Sons, Ltd.