NEUROLOGIC SYNDROME IN 25 WORKERS FROM AN ALUMINUM SMELTING PLANT
NEUROLOGIC SYNDROME IN 25 WORKERS FROM AN ALUMINUM SMELTING PLANT
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DOI：
10.1001/archinte.152.7.1443
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发表时间：
1992-07-01
影响因子：
--
通讯作者：
TOWNES, BD
中科院分区：
文献类型：
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作者：
WHITE, DM;LONGSTRETH, WT;TOWNES, BD
背景- 这篇文章扩展了一个早期系列的三个神经综合征患者，谁都曾在铝冶炼厂工作。- 来自同一工厂的25名有症状的工人被转诊进行标准化评估，包括完成健康问卷、神经系统检查和神经心理学评估。根据暴露水平和暴露持续时间计算每个工人的暴露指数，其中暴露最大。该指数与症状、体征和神经心理学测试评分相关。- 22名（88%）患者报告经常失去平衡，21名（84%）报告记忆丧失。神经系统检查显示21例（84%）患者存在运动不协调的体征。神经心理学测试结果显示，某些功能领域（如语言智商）得以保留，而其他方面（尤其是记忆功能）则受到严重损害。在记忆测试中，70%至75%的人表现出轻度或更大的损害。大多数人（19人中的17人，或89%）在明尼苏达多相人格调查中表现出抑郁症。暴露指数与不协调的体征和症状显著相关。- 这项研究和其他在人类和动物中的研究支持存在一种以不协调、记忆力差、抽象推理障碍和抑郁为特征的综合征。最有可能的原因是暴露在铅中。
Background. - This article expands on an earlier series of three patients with a neurologic syndrome, who had all worked in an aluminum smelting plant.Methods. - Twenty-five symptomatic workers from the same plant were referred for a standardized evaluation, including completion of a health questionnaire, neurologic examination, and neuropsychologic evaluation. An exposure index was calculated for each worker based on level and duration of exposure in the potroom, where exposures were the greatest. This index was correlated with symptoms, signs, and neuropsychologic test scores.Results. - Twenty-two (88%) of the patients reported frequent loss of balance, and 21 (84%) reported memory loss. Neurologic examination revealed signs of incoordination in 21 (84%) of the patients. Neuropsychologic test results showed preservation in certain spheres of functionining, such as verbal IQ, with substantial impairment in others, particularly memory functioning. On memory tests, 70% to 75% showed mild or greater impairment. The majority (17 of 19 tested, or 89%) showed depression on the Minnesota Multiphasic Personality Inventory. The exposure index was significantly correlated with signs and symptoms of incoordination.Conclusions. - This study and others in humans and animals support the existence of a syndrome characterized by incoordination, poor memory, impairment in abstract reasoning, and depression. Aluminum exposure in the potroom seems the most likely cause.