Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
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核受体对 NRF2 信号通路的调节：对癌症的影响。
DOI：
10.1016/j.bbamcr.2014.05.003
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发表时间：
2014-09-01
影响因子：
5.1
通讯作者：
Tang, Xiuwen
中科院分区：
文献类型：
--
作者：
Namani, Akhileshwar;Li, Yulong;Tang, Xiuwen
核因子-红细胞2 p45相关因子2（NRF 2，也称为Nfe 212）通过激活一系列抗氧化反应元件依赖性基因的表达，在调节细胞防御亲电和氧化应激中起关键作用。一方面，NRF 2激活剂已用于癌症预防和治疗与氧化应激相关的疾病的临床试验;另一方面，在许多类型的肿瘤中，NRF 2的组成性激活有助于癌细胞的存活和生长，以及对抗癌治疗的抗性。在这篇综述中，我们提供了一个概述的NRF 2信号通路，并讨论其在致癌作用。我们还介绍了核受体对NRF 2的抑制作用。此外，我们还讨论了核受体调节NRF 2信号通路在健康和疾病中的生物学意义。最后，我们讨论了核受体抑制NRF 2对癌症治疗的可能影响。(C)2014爱思唯尔有限公司版权所有。
Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe212) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have been used in clinical trials for cancer prevention and the treatment of diseases associated with oxidative stress; on the other hand, constitutive activation of NRF2 in many types of tumors contributes to the survival and growth of cancer cells, as well as resistance to anticancer therapy. In this review, we provide an overview of the NRF2 signaling pathway and discuss its role in carcinogenesis. We also introduce the inhibition of NRF2 by nuclear receptors. Further, we address the biological significance of regulation of the NRF2 signaling pathway by nuclear receptors in health and disease. Finally, we discuss the possible impact of NRF2 inhibition by nuclear receptors on cancer therapy. (C) 2014 Elsevier B.V. All rights reserved.