Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study
Human menopausal gonadotropin versus recombinant follicle-stimulating hormone in normogonadotropic women down-regulated with a gonadotropin-releasing hormone agonist who were undergoing in vitro fertilization and intracytoplasmic sperm injection: a prospective randomized study
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DOI：
10.1016/s0015-0282(01)01973-2
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发表时间：
2001-09-01
影响因子：
6.7
通讯作者：
Rasmussen, PE
中科院分区：
文献类型：
--
作者：
Westergaard, LG;Erb, K;Rasmussen, PE
目的：评价经鼻(IN)和皮下(SC)GnRH-a联合hMG和rFSH下调垂体功能的临床和内分泌效果。设计：前瞻性随机研究。地点：大学医院，体外受精室。患者(S)：379名符合体外受精或ICSI条件的促性腺激素正常的妇女。干预(S)：随机分为鼻内(IN)或SC GnRH-a和hMG或rFSH。主要结局指标(S)：取卵、胚胎发育、临床妊娠率和分娩率。结果(S)：随机分为4组：IN/HMG组(n=10 0)，IN/FSH组(n=98)，SC/HMG组(n=89)，SC/FSH组(n=92)。四组受精卵的平均取卵数、可移植胚胎数和移植胚胎数相似。IN/HMG组每开始一个周期的临床妊娠率显著高于SC/FSH组(P
Objective: To evaluate clinical and endocrinological effects of intranasal (IN) vs. subcutaneous (SC) GnRH-a for pituitary down-regulation combined with hMG vs. rFSH.Design: Prospective, randomized study.Setting: University hospital, IVF unit.Patient(s): Three hundred seventy-nine normogonadotropic women eligible for IVF or ICSI.Intervention(s): Randomization to intranasal (IN) or SC GnRH-a and to hMG or rFSH.Main Outcome Measure(s): Oocytes retrieved, embryos developed, clinical pregnancy, and delivery rates. Serum hormone concentrations on stimulation days 1 (S1) and 8 (S8), and oocyte pick-up (OPU) day.Result(s): After randomization, four groups were formed: IN/hMG (n = 100), IN/FSH (n = 98), SC/hMG (n = 89), and SC/FSH (n = 92). Mean number of oocytes retrieved and of transferable and transferred embryos were similar in the four groups. Clinical pregnancy rate per started cycle was significantly higher in the IN/HMG group than in the SC/FSH group (P