A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies
A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies
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DOI：
10.2967/jnumed.121.262464
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发表时间：
2022-02-01
影响因子：
9.3
通讯作者：
Buvat, Irene
中科院分区：
文献类型：
--
作者：
Orlhac, Fanny;Eertink, Jakoba J.;Buvat, Irene
PET图像采集和重建参数对SUV测量或放射组学特征值的影响已被广泛记录。这种扫描仪效应不利于预测或预后模型的设计和验证，并限制了大型多中心队列的使用。为了减少这种扫描器效应的影响，已经提出了ComBat方法，并且现在在各种上下文中使用。本文的目的是解释和说明ComBat的使用基于实际的例子。我们还给出了不满足ComBat假设的示例，因此不应使用ComBat。
The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.