Graft versus host disease: New insights into A2A receptor agonist therapy.
Graft versus host disease: New insights into A2A receptor agonist therapy.
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DOI：
10.1016/j.csbj.2014.12.003
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发表时间：
2015
影响因子：
6
通讯作者：
Kang EM
中科院分区：
文献类型：
--
作者：
Jones KR;Kang EM
同种异体移植可以治愈许多疾病，包括镰状细胞病，慢性肉芽肿病（CGD），严重联合免疫缺陷（SCID）和许多类型的癌症。然而，有几个相关的风险，可能导致严重的免疫反应，在某些情况下，死亡。这种发病率大部分与移植物抗宿主病（GVHD）有关[1]。GVHD是一种免疫介导的反应，其中供体T细胞将宿主识别为抗原性外源，导致供体T细胞扩增并攻击宿主组织。目前用免疫抑制剂治疗近期移植患者以防止这种反应的方法仅取得部分成功，强调需要新的GVHD治疗和预防方法。最近，出现了通过使用腺苷激动剂靶向腺苷A2A受体（A2AR）的新策略。这些激动剂已显示在体外可增加TGFβ诱导的FoxP3+调节性T细胞（T细胞）的产生，在体内可改善体重增加和死亡率，并抑制GVHD鼠模型中促炎细胞因子的释放[2，3]。涉及A2AR激动剂的体外和体内的阳性结果是有希望的，这表明A2AR激动剂应该是临床GvHD管理的一部分。
Allogeneic transplantation can cure many disorders, including sickle cell disease, chronic granulomatous disease (CGD), severe combined immunodeficiency (SCID) and many types of cancers. However, there are several associated risks that can result in severe immunological reactions and, in some cases, death. Much of this morbidity is related to graft versus host disease (GVHD) [1]. GVHD is an immune mediated reaction in which donor T cells recognize the host as antigenically foreign, causing donor T cells to expand and attack host tissues. The current method of treating recent transplant patients with immunosuppressants to prevent this reaction has met with only partial success, emphasizing a need for new methods of GVHD treatment and prevention. Recently, a novel strategy has emerged targeting adenosine A2A receptors (A2AR) through the use of adenosine agonists. These agonists have been shown in vitro to increase the TGFβ-induced generation of FoxP3+ regulatory T cells (Tregs) and in vivo to improve weight gain and mortality as well as inhibit the release of pro-inflammatory cytokines in GVHD murine models [2,3]. Positive results involving A2AR agonists in vitro and in vivo are promising, suggesting that A2AR agonists should be a part of the management of clinical GvHD.
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DOI：
10.1084/jem.20061097
发表时间：
2006-11-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lappas CM;Day YJ;Marshall MA;Engelhard VH;Linden J
通讯作者：
Linden J
影响因子：
4.8
作者：
Messina, C.;Faraci, M.;Calore, E.
通讯作者：
Calore, E.
影响因子：
4.4
作者：
Naganuma, Makoto;Wiznerowicz, Elizabeth B.;Ernst, Peter B.
通讯作者：
Ernst, Peter B.
影响因子：
2.9
作者：
Melani, Alessia;Corti, Francesca;Pedata, Felicita
通讯作者：
Pedata, Felicita
影响因子：
5.5
作者：
Lappas, Courtney M.;Liu, Po-Ching;Malech, Harry L.
通讯作者：
Malech, Harry L.