Three-dimensional reconstruction of the fibres of sickle cell haemoglobin
Three-dimensional reconstruction of the fibres of sickle cell haemoglobin
复制标题
镰状细胞血红蛋白纤维的三维重建
作者：
G. Dykes;R. H. Crepeau;S. Edelstein
对直径为 20 nm 的 HbS 纤维的电子显微照片进行三维重建，揭示了由 4 股线组成的内螺旋核心，被 10 股外螺旋包围，总共 14 股。这些股线以大致六角形堆积排列，产生不寻常的螺旋结构，其特征是多种分子间接触和非圆形横截面。
Three-dimensional reconstruction of electron micrographs of the 20-nm diameter fibres of HbS reveals an inner helical core of four strands surrounded by an outer helix of 10 strands to give a total of 14 strands. The strands are arranged with roughly hexagonal packing to produce an unusual helical structure which features a variety of intermolecular contacts and a non-circular cross section.