Absorption and swelling characteristics of silver (I) antimicrobial wound dressings
Absorption and swelling characteristics of silver (I) antimicrobial wound dressings
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DOI：
10.1177/0040517510380778
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发表时间：
2011-03
影响因子：
2.3
通讯作者：
D. Parikh;T. Fink;A. DeLucca;A. Parikh
中科院分区：
文献类型：
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作者：
D. Parikh;T. Fink;A. DeLucca;A. Parikh
湿润伤口敷料的一个重要特性是它们能够溶胀和吸收伤口渗出物，同时在伤口部位保持潮湿的气氛。在SRRC，我们之前已经从CM棉的钠盐中开发了抗微生物羧甲基化银钠（CM）棉印花布，并从四种市售藻酸盐湿性伤口敷料中开发了藻酸银钙钠。作为正在进行的银抗菌剂研究的一部分，本报告描述了这些银抗菌敷料与市售海藻酸钙钠敷料和印花布（对照品）在水中和0.9%氯化钠溶液（生理盐水）中浸泡8小时和1周后的溶胀性。此外，溶胀特性与敷料的生理盐水吸收率（g/g）相关。经银处理的Sorbsan、Kaltostat、Curasorb、Algadine和棉-CM-印花布显示出纤维直径的非常显著的增加：NaCl 8小时>水8小时>干燥，尽管略小于对照藻酸盐敷料。大部分溶胀发生在润湿的前8小时，持续润湿一周几乎没有引起溶液的额外吸收。纤维只在直径上膨胀，而在长度上不膨胀。所有的纤维在盐水中的溶胀比在水中的溶胀大。这些银敷料经证实的膨胀性，以及敷料已知的吸收和抗菌特性，应使其适用于治疗有感染风险的渗出性伤口。随着对这些敷料的了解越来越多，可能需要进行临床试验来评估其疗效。
An important characteristic of moist wound dressings is their ability to swell and absorb exudates from the wound, while maintaining a moist atmosphere at the wound site. At the SRRC, we have previously developed antimicrobial silversodium-carboxymethylated (CM)-cotton printcloth from the sodium salt of CM-cotton, and silver-Ca-Na alginates from four commercially available alginate moist wound dressings. As part of ongoing research on silver antimicrobials, this report delineates the swellabilty of these silver antimicrobial dressings compared to commercially available calcium-sodium alginate dressings and printcloth (controls) in water and in 0.9% sodium chloride solution (saline) after 8 hours and after one week of immersion. Additionally, the swelling characteristics are correlated with the absorption of saline g/g of the dressing. Silver treated Sorbsan, Kaltostat, Curasorb, Algisite, and cotton-CM-printcloth showed a very significant increase in diameter of the fibers: NaCl 8 hr > water 8 hr > dry, albeit slightly less than the control alginate dressings. The majority of the swelling took place in the first eight hours of wetting, and continued wetting for one week caused little additional uptake of the solution. Fibers swell only in diameter and not in length. All the fibers had greater swelling in saline as compared with those in water. The proven swellabilty of these silver dressings, taken together with the known absorptive and antimicrobial properties of the dressings should make them suitable for treatment of exudative wounds that are at risk for infection. As more is learned about these dressings, clinical trials may be warranted to evaluate their efficacy.