MITOTIC RATES GOBLET CELL INCREASE AND HISTOCHEMICAL CHANGES IN MUCUS IN RAT BRONCHIAL EPITHELIUM DURING EXPOSURE TO SULPHUR DIOXIDE
MITOTIC RATES GOBLET CELL INCREASE AND HISTOCHEMICAL CHANGES IN MUCUS IN RAT BRONCHIAL EPITHELIUM DURING EXPOSURE TO SULPHUR DIOXIDE
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DOI：
10.1002/path.1700960111
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发表时间：
1968-01-01
期刊：
影响因子：
--
通讯作者：
REID, L
中科院分区：
文献类型：
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作者：
LAMB, D;REID, L
MATERIALS AND METHODSFortyeight rats bred from pathogen-free rats (Anticimex Stockholm) were used for this investigation. The rats were divided into three groups, one of sixteen, one of fourteen and one of eighteen. Each group was used for a different experiment and exposed for the periods shown in table I. In the first two experiments the timing of exposure was so arranged that in each experiment all animals were killed at the same time, roughly 20 hr after their last exposure to sulphur dioxide. For mitotic counts three animals were used from each exposure time in the first experiment and one from each exposure time in the second experiment. The remaining animals were used for studying the uptake of radioactive sulphate. In the third experiment all were used to investigate the persistence of the changes. Three were kept as controls and the remaining 15 were exposed to SO2 for 3 wk only, after which groups of three animals were killed 1 day and 4, 7, 14 and 35 days after exposure. The irritant, sulphur dioxide, was applied as previously described (Reid, 1963) at a concentration of about 400 ppm for periods of 3 hr a day, 5 days a week.
