Boron neutron capture therapy for malignant gliomas
Boron neutron capture therapy for malignant gliomas
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DOI：
10.3109/07853890008995913
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发表时间：
2000-02-01
影响因子：
4.4
通讯作者：
Ma, RM
中科院分区：
文献类型：
--
作者：
Diaz, AZ;Coderre, JA;Ma, RM
硼中子俘获治疗（BNCT）代表了一种有前途的模式，相对选择性的辐射剂量输送到肿瘤组织。硼-10原子核优先捕获慢“热”中子，并且在捕获后立即进行（10）B（n，alpha）（7）Li反应。由该反应产生的高能重锂离子和氦离子的电离径迹长度仅约为一个电池直径（类似于14 μ m）。由于它们的高线性能量转移（LET），这些离子具有用于控制肿瘤生长的高相对生物学有效性（RBE）。肿瘤（如多形性胶质母细胞瘤（GBM））的有效BNCT的关键是，与正常大脑的重要结构相比，硼-10在肿瘤（包括浸润的GEM细胞）中的优先积累。如果肿瘤中硼-10浓度足够高（相当于10（9）个硼-10原子/细胞），热中子注量足够大（相当于10（12）个中子/ cm（2）），那么肿瘤细胞中硼-10浓度与正常脑细胞中硼-10浓度的比值将在很大程度上决定BNCT的治疗效果。
Boron neutron capture therapy (BNCT) represents a promising modality for a relatively selective radiation dose delivery to the tumour tissue. Boron-10 nuclei capture slow 'thermal' neutrons preferentially and, upon capture, promptly undergo (10)B(n,alpha)(7)Li reaction. The ionization tracks of energetic and heavy lithium and helium ions resulting from this reaction are only about one cell diameter in length (similar to 14 mu m). Because of their high linear energy transfer (LET) these ions have a high relative biological effectiveness (RBE) for controlling tumour growth. The key to effective BNCT of tumours, such as glioblastoma multiforme (GBM), is the preferential accumulation of boron-10 in the tumour, including the infiltrating GEM cells, as compared with that in the vital structures of the normal brain. Provided that a sufficiently high tumour boron-10 concentration (similar to 10(9) boron-10 atoms/cell) and an adequate thermal neutron fluence (similar to 10(12) neutrons/ cm(2)) are achieved, it is the ratio of the boron-10 concentration in tumour cells to that in the normal brain cells that will largely determine the therapeutic gain of BNCT.