NK cytolysis is dependent on the proportion of HLA-G expression
NK cytolysis is dependent on the proportion of HLA-G expression
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NK 细胞溶解取决于 HLA-G 表达的比例。
DOI：
10.1016/j.humimm.2012.12.005
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发表时间：
2013-03-01
期刊：
影响因子：
2.7
通讯作者：
Yan, Wei-Hua
中科院分区：
文献类型：
--
作者：
Chen, Bao-Guo;Xu, Dan-Ping;Yan, Wei-Hua
人类白细胞抗原G对多种免疫细胞的抑制作用已被证实。恶性病变细胞中人类白细胞抗原-G的表达比例从阴性到100%。然而，不同比例的HLA-G表达对NK细胞杀伤作用的影响仍有待进一步研究。本研究探讨了NK细胞对白血病细胞株K562不同比例的人类白细胞抗原-G1表达的杀伤作用。通过检测NK细胞表面CD107a的表达来分析NK细胞的杀伤活性。结果表明，NK细胞杀伤活性受HLAG1表达的抑制，且呈比例依赖关系(r=0.925，p=0.008)。我们的研究为进一步了解人类白细胞抗原-G1在恶性细胞免疫逃逸NK细胞中的作用提供了依据。(C)2012年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版，版权所有。
The suppressive functions of HLA-G to various immune cells have been well established. The proportion of HLA-G expression in malignant lesion cells was found from negative to 100%. However, effects for the different proportion of HLA-G expression on the cytolysis of NK cells remain to be explored. In this study, NK cytolysis to the various proportion of HLA-G1 expression on leukemia cell line K562 was investigated. Analysis of NK cell cytotoxicity was by detecting the NK cell surface CD107a expression. Data showed that NK cell cytolysis could be inhibited by the HLA-G1 expression and in a manner of HLA-G1 expression proportion dependent manner (r = 0.925, p = 0.008). Our study provided further understanding for the roles of HLA-G1 expression in malignant cell immune escaping from NK cells. (c) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.