Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.
Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.
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DOI：
10.1016/j.gene.2006.05.006
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发表时间：
2006-09
期刊：
影响因子：
3.5
通讯作者：
Toru Sato;Mitsuhiro Endoh;H. Yoshida;Suzuki Yasuo;T. Katsuno;Y. Saito;K. Isono;H. Koseki
中科院分区：
文献类型：
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作者：
Toru Sato;Mitsuhiro Endoh;H. Yoshida;Suzuki Yasuo;T. Katsuno;Y. Saito;K. Isono;H. Koseki
脊椎动物多梳族 (PcG) 基因编码的蛋白质形成大型多聚体和染色质相关复合物，参与发育必需基因的稳定抑制。 Rnf110 和 Phc2 被证明是 HeLa 细胞中哺乳动物 PcG 多聚复合物的组成部分。在这里，我们报告了 Rnf110 突变小鼠中派尔氏集结 (PP) 发育的缺陷，该缺陷因 Phc2 突变而协同放大。 PP的发育涉及妊娠晚期淋巴和间充质细胞之间的一系列诱导相互作用以及随后的分化和增殖。 Rnf110 和 Phc2 突变通过以基因剂量依赖性方式影响 PP 原基中淋巴谱系细胞的增殖来损害 PP 原基的发育。我们认为，PcG 复合物可能通过 IL-7Rα 介导某些诱导信号，以允许淋巴诱导细胞在 PP 器官发生过程中充分增殖。
The vertebrate Polycomb Group (PcG) genes encode proteins that form large multimeric and chromatin-associated complexes implicated in the stable repression of developmentally essential genes. Rnf110 and Phc2 are shown to be components of mammalian PcG multimeric complexes in HeLa cells. Here we report defects in Peyer's patch (PP) development in Rnf110 mutant mice, which is synergically exaggerated by Phc2 mutation. PP development involves a series of inductive interactions and subsequent differentiation and proliferation between lymphoid and mesenchymal cells in late gestational stage. Rnf110 and Phc2 mutations impair development of PP anlagen by affecting proliferation of lymphoid lineage cells populated in PP anlagen in gene-dosage dependent manner. We suggest that PcG complexes may act to mediate certain inductive signals maybe through IL-7Rα to allow sufficient proliferation of lymphoid inducer cells during PP organogenesis.