Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats.
Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats.
复制标题
后区病变和双侧膈下传入迷走神经切断术对依米丁诱导的大鼠条件性味觉回避的影响。
DOI：
10.1016/j.physbeh.2021.113565
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发表时间：
2021
影响因子：
2.9
通讯作者：
Funahashi Makoto
中科院分区：
文献类型：
--
作者：
Su Shaoyi;Fujita Mayu;Wei Zimo;Huang Helai;Yoshizawa Tomohiko;Inui Tadashi;Funahashi Makoto
我们研究了最后区损伤和选择性迷走神经传入纤维切断对大鼠呕吐的影响。我们评估了在用盐酸依马林（5.54 mg/kg，i. p.，1%BW）。在三组大鼠中测量CTA：双侧小脑下传入迷走神经切断术组、最后区损伤组和假损伤组。双侧迷走神经切断术组和假手术组大鼠在试验日期的2天内显示获得CTA。味觉回避在最后区损伤组中从未出现过。这些结果表明，最后区在诱发呕吐中起着至关重要的作用。
We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea.