Failed fertilization: is it predictable?
Failed fertilization: is it predictable?
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DOI：
10.1097/00001703-200306000-00001
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发表时间：
2003-06-01
影响因子：
2.1
通讯作者：
Arici, A
中科院分区：
文献类型：
--
作者：
Mahutte, NG;Arici, A
综述的目的本综述的目的是严格检查筛查试验预测受精失败的能力。最近的发现受精失败发生在5-10%的体外受精周期和2-3%的卵胞浆内单精子注射周期。受精失败可能是由于精子受损、卵母细胞缺陷或体外精子/卵母细胞培养基缺陷所致。在体外受精环境中，大多数病例是由雄性因子缺乏引起的，而卵母细胞激活失败是卵胞浆内单精子注射后受精失败的最常见原因。虽然标准精液分析预测受精失败的能力有限，但严格的精子形态学标准、精子结合率和透明质酸诱导的顶体反应试验提供了更大的能力来避免这种结果。取卵当天精液样本的质量和先前体外受精周期的受精性能也可以指导卵胞浆内单精子注射的适当使用。然而，后者的技术在非男性因素不孕症的情况下，常规使用是abutentiated.Summary不断改进的技术强调在此分析提供了更好的能力来预测失败的受精。
Purpose of review The purpose of this review is to critically examine the ability of screening tests to predict fertilization failure.Recent findings Failed fertilization occurs in 5-10% of in-vitro fertilization cycles and 2-3% of intracytoplasmic sperm injection cycles. Failed fertilization may result from impaired spermatozoa, oocyte deficiencies or defects in the in-vitro sperm/oocyte medium. In the in-vitro fertilization setting most cases are caused by male factor deficiencies, whereas failure of oocyte activation is the most common cause of failed fertilization after intracytoplasmic sperm injection. Although the standard semen analysis has limited ability to predict fertilization failure, strict sperm morphology criteria, sperm-zona binding ratios and zona pellucida induced acrosome reaction tests provide increased capacity to avoid this outcome. The quality of the semen sample on the day of oocyte retrieval and fertilization performance in previous in-vitro fertilization cycles may also guide the appropriate use of intracytoplasmic sperm injection. However, the routine use of the latter technique in cases of non-male factor infertility is contraindicated.Summary The ever improving techniques highlighted in this analysis offer improved ability to predict failed fertilization.