CARDIOVASCULAR-RESPONSES TO ELECTRICAL-STIMULATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS
CARDIOVASCULAR-RESPONSES TO ELECTRICAL-STIMULATION OF THE BED NUCLEUS OF THE STRIA TERMINALIS
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DOI：
10.1002/cne.903520206
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发表时间：
1995-02-06
影响因子：
2.5
通讯作者：
WILLIAMS, TJ
中科院分区：
文献类型：
--
作者：
DUNN, JD;WILLIAMS, TJ
为了确定终纹床核(BST)对心血管功能的影响是否可以定位于BST内特定的细胞构筑区域，用乌拉坦(1.3g/kg)麻醉的雄性SpragueDawley大鼠观察心血管反应部位。电刺激(50微安，50赫兹，脉宽0.5ms)，通过立体定向放置的玻璃半微电极，定位于BST。假刺激的动物作为对照。刺激部位与BST内细胞结构不同的区域相关，平均动脉压(MAP)的变化被进行统计分析。系统地探测BST的心血管反应部位显示，诱发反应与不同的细胞结构区域之间存在相关性。刺激内侧BST使MAP升高，刺激BST外侧使MAP降低。升压和降压反应都是从前连合腹侧区域诱发的。升压反应从紧邻腹侧到前连合的区域被激发，降压反应在刺激更腹侧的区域之后被激发。所有亚核对微量注射20-30nL谷氨酸钠均表现出确证的心血管反应。综上所述，这些数据提供了大量证据表明，BST，特别是在更多的吻部区域，由内侧加压区、外侧加压区和腹侧区组成，其中既有加压区，也有降压区。(C)1995年Wiley-Liss公司
To determine whether the influence of the bed nucleus of the stria terminalis (BST) on cardiovascular function can be localized to specific cytoarchitectural areas within the BST, urethane (1.3 g/kg)-anesthetized male Sprague-Dawley rats were probed for cardiovascular reactive sites. Electrical stimuli (50 mu A, 50 Hz, and a 0.5 ms pulse duration), delivered through stereotaxically placed glass semimicroelectrodes, were localized to the BST. Sham-stimulated animals served as controls. Stimulation sites were correlated with cytoarchitecturally distinct areas within the BST, and changes in mean arterial pressure (MAP) were subjected to statistical analysis.Systematically probing the BST for cardiovascular reactive sites showed a correlation between evoked responses and distinct cytoarchitectural areas. Stimulation of the medial BST produced increases in MAP; stimulation of the lateral aspect of the BST produced decreases in MAP. Both presser and depressor responses were evoked from the area ventral to the anterior commissure. Presser responses were elicited from the area immediatley ventral to the anterior commissure, and depressor responses followed stimulation of an area more ventral. All subnuclei showed corroborating cardiovascular responses to 20-30 nl microinjection of sodium glutamate. Taken together, these data provide substantial evidence to indicate that the BST, particularly at more rostral areas, consists of a medial presser area, a lateral depressor area, and a ventral area with both presser and depressor zones. (C) 1995 Wiley-Liss, Inc.