Supernormal conduction in cardiac tissue promotes concordant alternans and action potential bunching
Supernormal conduction in cardiac tissue promotes concordant alternans and action potential bunching
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DOI：
10.1103/physreve.83.040902
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发表时间：
2011-04-04
影响因子：
2.4
通讯作者：
Baer, Markus
中科院分区：
文献类型：
--
作者：
Echebarria, Blas;Roeder, Georg;Baer, Markus
可兴奋心脏组织中的超常传导（SNC）是指脉搏（或动作电位）速度随着与前一脉搏距离的减小而增加。在这里，我们采用一个简单的离子模型来研究SNC的动作电位（AP）的传播和交替在可兴奋的心脏组织的现象学的影响。我们使用分叉分析和模拟来研究SNC引起的传播AP之间的吸引力，从而导致AP对和聚束。它表明，SNC稳定和谐交替任意长的步调一维电缆。因此，螺旋波在二维组织模拟中表现出直的节线SNC在螺旋的情况下，正常的传导。
Supernormal conduction (SNC) in excitable cardiac tissue refers to an increase of pulse (or action potential) velocity with decreasing distance to the preceding pulse. Here we employ a simple ionic model to study the effect of SNC on the propagation of action potentials (APs) and the phenomenology of alternans in excitable cardiac tissue. We use bifurcation analysis and simulations to study attraction between propagating APs caused by SNC that leads to AP pairs and bunching. It is shown that SNC stabilizes concordant alternans in arbitrarily long paced one-dimensional cables. As a consequence, spiral waves in two-dimensional tissue simulations exhibit straight nodal lines for SNC in contrast to spiraling ones in the case of normal conduction.