Transforming-growth factor β1 Leu10Pro polymorphism and breast cancer morbidity
Transforming-growth factor β1 Leu10Pro polymorphism and breast cancer morbidity
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DOI：
10.1016/j.ejca.2006.08.021
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发表时间：
2007-01-01
影响因子：
8.4
通讯作者：
van Duijn, C. M.
中科院分区：
文献类型：
--
作者：
Ladd, A. M. Gonzalez-Zuloeta;Arias-Vasquez, A.;van Duijn, C. M.
tgf - β(1)在致癌过程中具有双重作用。在该基因中，密码子10中亮氨酸到脯氨酸的替换导致更高的tgf - β循环水平(1)。这种变异与乳腺癌风险的关系已被研究，但结果却相互矛盾。我们的目标是揭示这种多态性与乳腺癌风险的关系。参与鹿特丹研究的女性，包括143名乳腺癌患者，对这种多态性进行了基因分型。我们使用年龄作为时间变量进行了逻辑回归和生存分析。logistic回归分析显示脯氨酸携带者患乳腺癌的风险比非携带者高（OR = 1.4； 95%可信区间(CI) = 1.1-2.0）。生存分析显示，同一等位基因的携带者比非携带者患乳腺癌的风险更高（HR = 1.4, 95% CI = 1.1-2.0）。我们的数据表明，tgf - β (1) Leu10Pro多态性可能在乳腺癌风险中起作用。(c) 2006年Elsevier Ltd出版
TGF-beta(1) has a dual role in carcinogenesis. In this gene, a leucine to proline substitution in codon 10 leads to higher circulating levels of TGF-beta(1). This variant has been studied in relationship to the risk for breast cancer yielding contradicting results. We aim to unravel the relationship of this polymorphism and the risk of breast cancer. Women participating in the Rotterdam Study including 143 patients with incident breast cancer were genotyped for this polymorphism. We carried out a logistic regression and a survival analysis using age as the time variable. The logistic regression analysis showed an increased risk of breast cancer for Proline carriers (OR = 1.4; 95% confidence interval (CI) = 1.1-2.0) versus non-carriers. The survival analysis showed that carriers of the same allele had an increased risk of breast cancer (HR = 1.4, 95% CI = 1.1-2.0) against non-carriers.Our data suggest that the TGF-beta(1) Leu10Pro polymorphism might play a role in breast cancer risk. (c) 2006 Published by Elsevier Ltd.