Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia - The UCLA Family Study
Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia - The UCLA Family Study
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DOI：
10.1001/archpsyc.58.6.581
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发表时间：
2001-06-01
影响因子：
--
通讯作者：
Kendler, KS
中科院分区：
文献类型：
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作者：
Asarnow, RF;Nuechterlein, KH;Kendler, KS
背景：本研究通过确定儿童期发病的精神分裂症（COS）是成人发病的精神分裂症（AOS）的一种变体这一假设，通过确定 COS 先证者的一级亲属患精神分裂症以及精神分裂型和偏执型人格障碍的风险是否增加。方法：将 COS 先证者的亲属（n = 148）与注意力缺陷/多动障碍的亲属进行比较 (ADI-ID) (n=368) 和社区对照 (n=206) 先证者。采用适合年龄的结构化诊断访谈将 DSMIII-R 诊断分配给先证者及其亲属。家族精神病史是从多名知情者处获得的。亲属的诊断对先证者的诊断信息视而不见。本文报告了综合家族史、直接访谈信息和医疗记录的最终共识诊断。 结果：与 ADHD 父母（0.45%+/-0.45%， 0.91%+/-0.63%）和社区对照（0%）先证者。被诊断患有精神分裂症的 COS 先证者的父母首次发病的年龄较早。与社区对照父母（1.67%+/-1.17%）相比，COS先证者父母的回避型人格障碍风险（9.41%+/-3.17%）增加。结论：在现代家庭研究中，COS先证者父母中聚集和不聚集的精神疾病与成年精神分裂症患者父母中聚集和不聚集的疾病非常相似。这些发现为 COS 和 AOS 之间病因连续性的假设提供了令人信服的支持。
Background: This study tested the hypothesis that childhood-onset schizophrenia (COS) is a variant of adult-onset schizophrenia (AOS) by determining if first-degree relatives of COS probands have an increased risk for schizophrenia and schizotypal and paranoid personality disorders.Methods: Relatives of COS probands (n=148) were compared with relatives of attention-deficit/ hyperactivity disorder (ADI-ID) (n=368) and community control (n=206) probands. Age-appropriate structured diagnostic interviews were used to assign DSMIII-R diagnoses to probands and their relatives. Family psychiatric history was elicited from multiple informants. Diagnoses of relatives were made blind to information about probands' diagnoses. Final consensus diagnoses, which integrated family history, direct interview information, and medical records, are reported in this article.Results: There was an increased lifetime morbid risk for schizophrenia (4.95%+/-2.16%) and schizotypal personality disorder (4.20% +/- 12.06%) in the parents of COS probands compared with parents of ADHD (0.45%+/-0.45%, 0.91%+/-0.63%) and community control (0%) probands. The parents of COS probands diagnosed as having schizophrenia had an early age of first onset of schizophrenia. Risk for avoidant personality disorder (9.41%+/-3.17%) was increased in the parents of COS probands compared with parents of community controls (1.67%+/-1.17%).Conclusions: The psychiatric disorders that do and do not aggregate in the parents of COS probands are remarkably similar to the disorders that do and do not aggregate in the parents of adults with schizophrenia in modern family studies. These findings provide compelling support for the hypothesis of etiological continuity between COS and AOS.