Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples.
Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples.
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DOI：
10.3390/metabo7020018
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发表时间：
2017-05-16
期刊：
影响因子：
4.1
通讯作者：
Bathen TF
中科院分区：
文献类型：
--
作者：
Haukaas TH;Euceda LR;Giskeødegård GF;Bathen TF
尽管在早期发现和治疗策略方面取得了进展，但乳腺癌仍然是全球妇女癌症相关死亡的第二大原因。由于肿瘤生物学的异质性和复杂性，诊断相似的乳腺癌患者可能会有不同的预后和治疗反应。因此，有必要更深入地了解个体肿瘤的特性。癌细胞必须能够将营养物质转化为生物质，同时保持能量生产，这需要重新编程细胞中的中心代谢过程。这种现象越来越被认为是治疗的潜在靶点，也是可用于预后、风险分层和治疗监测的生物标志物的来源。磁共振（MR）代谢组学是一种广泛应用于转化研究的方法，旨在识别临床相关的代谢生物标志物或产生肿瘤分子生物学的新认识。离体质子高分辨率魔角旋转（HR MAS）MR波谱广泛用于以非破坏性方式研究中枢代谢过程。在这里，我们回顾了乳腺癌的HR MAS MR波谱研究结果与葡萄糖，氨基酸和胆碱代谢的现状。
Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast cancer patients with similar diagnosis might have different prognosis and response to treatment. Thus, deeper understanding of individual tumor properties is necessary. Cancer cells must be able to convert nutrients to biomass while maintaining energy production, which requires reprogramming of central metabolic processes in the cells. This phenomenon is increasingly recognized as a potential target for treatment, but also as a source for biomarkers that can be used for prognosis, risk stratification and therapy monitoring. Magnetic resonance (MR) metabolomics is a widely used approach in translational research, aiming to identify clinically relevant metabolic biomarkers or generate novel understanding of the molecular biology in tumors. Ex vivo proton high-resolution magic angle spinning (HR MAS) MR spectroscopy is widely used to study central metabolic processes in a non-destructive manner. Here we review the current status for HR MAS MR spectroscopy findings in breast cancer in relation to glucose, amino acid and choline metabolism.