Regulation of Dendrite and Spine Morphogenesis and Plasticity by Catenins
Regulation of Dendrite and Spine Morphogenesis and Plasticity by Catenins
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DOI：
10.1007/s12035-009-8068-x
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发表时间：
2009-08-01
影响因子：
5.1
通讯作者：
Arikkath, Jyothi
中科院分区：
文献类型：
--
作者：
Arikkath, Jyothi
在发育过程中和发育后，神经元中树突、棘和突触形态发生的适当调节对于神经回路的形成和维持至关重要。越来越清楚的是，钙粘蛋白-连环蛋白细胞粘附复合物，一种在上皮细胞中被广泛研究的复合物，调节神经元的形态发生。更有趣的是，连环蛋白，结合钙粘蛋白的胞质蛋白，调节神经元形态发生的多个方面，包括树突，棘和突触形态发生和可塑性，既独立于也依赖于它们结合钙粘蛋白的能力。在这篇综述中，我们研究了一些最近的和令人兴奋的研究，涉及个别连环蛋白在神经元形态发生和可塑性的各个方面。
The appropriate regulation of dendrite, spine, and synapse morphogenesis in neurons both during and after development is critical for the formation and maintenance of neural circuits. It is becomingly increasingly clear that the cadherin-catenin cell adhesion complex, a complex that has been widely studied in epithelia, regulates neuronal morphogenesis. More interestingly, the catenins, cytosolic proteins that bind to cadherins, regulate multiple aspects of neuronal morphogenesis including dendrite, spine, and synapse morphogenesis and plasticity, both independent of and dependent on their ability to bind cadherins. In this review, we examine some of the more recent and exciting studies that implicate individual catenins in various aspects of neuronal morphogenesis and plasticity.