Assessment of differences in linear growth among populations in the WHO Multicentre Growth Reference Study
Assessment of differences in linear growth among populations in the WHO Multicentre Growth Reference Study
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DOI：
10.1080/08035320500495514
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发表时间：
2006-04-01
期刊：
影响因子：
3.8
通讯作者：
Martines, Jose
中科院分区：
文献类型：
--
作者：
Garza, Cutberto;de Onis, Mercedes;Martines, Jose
目的：评估WHO多中心生长参考研究（MGRS）中人群的身长/身高差异，并评价合并数据以构建单一国际生长标准的适当性。研究方法：MGRS收集了来自不同种族背景和文化背景（巴西，加纳，印度，挪威，阿曼和美国）的8440名富裕儿童的生长数据和相关信息。合格标准包括母乳喂养，没有母亲吸烟和环境支持不受约束的增长。该研究结合了纵向（出生至24个月）和横截面（18-71个月）组件。对于纵向分量，母亲-婴儿配对在分娩时登记，并在接下来的2年中访问21次。在各研究中心采用严格的数据收集方法和标准化程序。我们评估了可归因于部位和个体的长度的总变异性、部位之间的长度/高度差异以及排除单个部位对剩余合并样本的样本数的影响。结果：归因于站点和站点内个人的总变异比例分别为3%和70%。长度和高度的差异范围分别为-0.33至+0.49和-0.41至+0.46标准差单位（SD），大多数值低于0.2 SD。对于第50、第3和第97个样本，排除单个位点的长度差异范围分别为-0.10至+0.07、-0.07至+0.13和-0.25至+0.09 SD。结论：6个地区儿童的线性生长具有显著的相似性，有必要将6个地区儿童的线性生长数据合并起来，建立一个从出生到5岁的统一的国际标准。
Aim: To assess differences in length/height among populations in the WHO Multicentre Growth Reference Study (MGRS) and to evaluate the appropriateness of pooling data for the purpose of constructing a single international growth standard. Methods: The MGRS collected growth data and related information from 8440 affluent children from widely differing ethnic backgrounds and cultural settings (Brazil, Ghana, India, Norway, Oman and the USA). Eligibility criteria included breastfeeding, no maternal smoking and environments supportive of unconstrained growth. The study combined longitudinal (birth to 24 mo) and cross-sectional (18-71 mo) components. For the longitudinal component, mother-infant pairs were enrolled at delivery and visited 21 times over the next 2 y. Rigorous methods of data collection and standardized procedures were applied across study sites. We evaluate the total variability of length attributable to sites and individuals, differences in length/height among sites, and the impact of excluding single sites on the percentiles of the remaining pooled sample. Results: Proportions of total variability attributable to sites and individuals within sites were 3% and 70%, respectively. Differences in length and height ranged from -0.33 to +0.49 and -0.41 to +0.46 standard deviation units (SDs), respectively, most values being below 0.2 SDs. Differences in length on exclusion of single sites ranged from -0.10 to +0.07, -0.07 to +0.13, and -0.25 to +0.09 SDs, for the 50th, 3rd and 97th percentiles, respectively. Corresponding values forheightranged from -0.09 to +0.08, -0.12 to +0.13, and -0.15 to +0.07 SDs.Conclusion: The striking similarity in linear growth among children in the six sites justifies pooling the data and constructing a single international standard from birth to 5 y of age.