Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations
Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations
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用于多米诺螺环化的催化双 1,1-H-抽象/插入
DOI：
10.1021/jacs.5b05735
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发表时间：
2015-07-22
影响因子：
15
通讯作者：
Li, Guigen
中科院分区：
文献类型：
--
作者：
Qiu, Jiang-Kai;Jiang, Bo;Li, Guigen
通过炔基/烯基官能团形成多个C-C键和双α，α-C（sp（3））-H夺取/插入，建立了1，7-烯炔与简单环烷烃和环-1，3-二羰基的催化多米诺螺环化反应。反应涉及加成，6-exo-dig环化和自由基偶联序列在方便的催化条件下，并提供了一个简洁的访问螺环戊二烯[c]喹啉类化合物的产率较高。
A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and Cyclo-1,3-dicarbonyls has been established via multiple C-C bond formations from alkynyl/alkenyl functions and dual alpha,alpha-C(sp(3))-H abstractibn/insertion The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.