Septicemia with Streptococcus pseudopneumoniae: report of three cases with an apparent hepatic or bile duct association
Septicemia with Streptococcus pseudopneumoniae: report of three cases with an apparent hepatic or bile duct association
复制标题
DOI：
10.3109/23744235.2016.1157896
复制
发表时间：
2016-01-01
影响因子：
5.8
通讯作者：
Scholz, Christian F. P.
中科院分区：
文献类型：
--
作者：
Fuursted, Kurt;Littauer, Pia Jeanette;Scholz, Christian F. P.
2004 年，假肺炎链球菌被描述为一种新的人类病原体，在一系列通常与呼吸道相关的临床感染中得到承认。该报告表明，假肺炎链球菌有可能引起侵袭性感染。在三名患者的血培养中，恢复了非典型肺炎链球菌（非荚膜、非血清型、环境气氛下对奥托钦敏感且胆汁中溶）的生长。所有三名患者都有血液病史（骨髓增生异常综合征和多发性骨髓瘤），并且有明显的与肝脏或胆管相关的感染源。所有分离株均进行基因组测序，随后通过多位点序列分析 (MLSA) 鉴定为假肺炎链球菌。基于肺炎链球菌方案的多位点序列分型（MLST）显示未知的序列类型，抗菌谱和耐药组显示没有抗生素耐药性。
Streptococcus pseudopneumoniae was described in 2004 as a new human pathogen, acknowledged in a range of clinical infections typically associated to the respiratory tract. This report demonstrates that S. pseudopneumoniae has the potential to cause invasive infection. In blood cultures from three patients, growth of an atypical Streptococcus pneumoniae (non-capsular, non-serotypeable, optochin susceptible under ambient atmosphere and bile-intermediately soluble) was recovered. All three patients had a history of a haematological disease (myelodysplastic syndrome and multiple myeloma) and an apparent origin of infection related to the liver or bile duct. All isolates were genome sequenced and subsequently identified as S. pseudopneumoniae by multi-locus sequence analysis (MLSA). Multi-locus sequence typing (MLST) based on the S. pneumoniae scheme revealed unknown sequence types and the antibiogram and resistome revealed no antibiotic resistance.