In vivo effects of BISGMA - a component of dental composite - on male mouse reproduction and fertility
In vivo effects of BISGMA - a component of dental composite - on male mouse reproduction and fertility
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DOI：
10.1002/jbm.a.30667
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发表时间：
2006-07-01
影响因子：
4.9
通讯作者：
Darmani, Homa
中科院分区：
文献类型：
--
作者：
Al-Hiyasat, Ahmad S.;Darmani, Homa
本研究的目的是研究树脂单体双酚 A 甘油酯二甲基丙烯酸酯 (BISGMA) 对成年雄性小鼠生育力的影响。雄性瑞士小鼠被给予不同浓度的 BISGMA（0、25 和 100 μg/kg）28 天，并通过在暴露期后将这些雄性小鼠与未处理的雌性小鼠交配来评估对生育力的影响。结果表明，与对照小鼠相比，当雄性小鼠接触 BISGMA 时，其生育能力显着降低。在与暴露于 BISGMA 的雄性交配的雌性中，怀孕率以及可存活胎儿的数量显着降低。在与暴露于 BISGMA 的雄性交配的雌性中，植入总数中的吸收数量显着增加。此外，发生吸收的女性数量也显着增加。还观察到体重以及睾丸和包皮腺重量的显着减少。与对照组相比，暴露于 BISGMA 的男性的精囊重量显着增加。睾丸精子数量、附睾精子数量和精子产生效率显着下降。总之，雄性小鼠接触 BISGMA 会导致生殖系统和生育能力受损。 (c) 2006 年 Wiley 期刊公司
The aim of this study is to investigate the effects of the resin monomer bisphenol A glycerolate dimethacrylate (BISGMA) on adult male mouse fertility. Male Swiss mice were administered various concentrations of BISGMA (0, 25, and 100 mu g/kg) for a period of 28 days, and the effects on fertility was assessed by breeding these males with untreated female mice after the exposure periods. The results showed that fertility was significantly reduced when male mice were exposed to BISGMA, in comparison with their control counterparts. In females mated with males exposed to BISGMA, there was a significant reduction in the pregnancy rates as well as the number of viable fetuses. The number of resorptions out of the total number of implantations was significantly increased in females mated with males that had been exposed to BISGMA. Furthermore, the number of females with resorptions was also significantly increased. Significant reductions in bodyweight and weights of the testis and preputial glands were also observed. The weights of the seminal vesicles were significantly increased in males exposed to BISGMA in comparison with their control counterparts. There were significant reductions in testicular sperm counts, epididymal sperm counts and in the efficiency of sperm production. In conclusion, exposure of male mice to BISGMA results in an impairment of the reproductive system and fertility. (c) 2006 Wiley Periodicals, Inc.