Genomic analyses provide insights into the history of tomato breeding
Genomic analyses provide insights into the history of tomato breeding
复制标题
基因组分析提供了对番茄育种历史的深入了解
DOI：
10.1038/ng.3117
复制
发表时间：
2014-11-01
期刊：
影响因子：
30.8
通讯作者：
Huang, Sanwen
中科院分区：
文献类型：
--
作者：
Lin, Tao;Zhu, Guangtao;Huang, Sanwen
作物驯化和育种的历史被记录在基因组中。尽管番茄是植物生物学和育种的模式物种，但人类选择改变其基因组的本质在很大程度上仍不清楚。本文以360份番茄种质的基因组序列为基础，对番茄的进化进行了综合分析。我们提供的证据表明，驯化和改良集中在两组独立的数量性状基因座(∼)上，导致现代番茄果实QTL比其祖先大100倍。此外，我们发现了现代加工番茄的一个主要基因组特征，鉴定了赋予粉红色果实颜色的致病变异，并准确地可视化了与野生导入相关的连锁阻力。这项研究概述了历史选择的成就和成本，并为进一步改进提供了分子洞察力。
The histories of crop domestication and breeding are recorded in genomes. Although tomato is a model species for plant biology and breeding, the nature of human selection that altered its genome remains largely unknown. Here we report a comprehensive analysis of tomato evolution based on the genome sequences of 360 accessions. We provide evidence that domestication and improvement focused on two independent sets of quantitative trait loci (QTLs), resulting in modern tomato fruit ∼100 times larger than its ancestor. Furthermore, we discovered a major genomic signature for modern processing tomatoes, identified the causative variants that confer pink fruit color and precisely visualized the linkage drag associated with wild introgressions. This study outlines the accomplishments as well as the costs of historical selection and provides molecular insights toward further improvement.