Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity.
Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity.
复制标题
脂联素和甲状腺癌：深入了解脂联素和肥胖之间的关联
DOI：
10.14336/ad.2020.0919
复制
发表时间：
2021-04
影响因子：
7.4
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zhou Y;Yang Y;Zhou T;Li B;Wang Z
近几十年来，甲状腺癌的发病率和诊断率急剧上升，甲状腺癌现已成为世界上最常见的内分泌癌症。甲状腺癌的发病是隐匿的，其进展缓慢且难以检测。因此，早期预防和治疗具有重要的战略意义。此外，深入探讨甲状腺癌的发病机制是早期预防和治疗的关键。大量证据支持肥胖是甲状腺癌的独立危险因素。肥胖状态下的脂肪组织功能障碍伴随着多种脂肪细胞因子的失调。脂联素（APN）是最关键的脂肪细胞因子之一，其与肥胖及肥胖相关疾病的关系已逐渐成为研究热点。近年来，APN与甲状腺癌的关系受到越来越多的关注。本文旨在系统回顾以往研究，突出APN，关注APN与肥胖和甲状腺癌的关系，揭示其致病机制。
In recent decades, the incidence and diagnosis of thyroid cancer have risen dramatically, and thyroid cancer has now become the most common endocrine cancer in the world. The onset of thyroid cancer is insidious, and its progression is slow and difficult to detect. Therefore, early prevention and treatment have important strategic significance. Moreover, an in-depth exploration of the pathogenesis of thyroid cancer is key to early prevention and treatment. Substantial evidence supports obesity as an independent risk factor for thyroid cancer. Adipose tissue dysfunction in the obese state is accompanied by dysregulation of a variety of adipocytokines. Adiponectin (APN) is one of the most pivotal adipocytokines, and its connection with obesity and obesity-related disease has gradually become a hot topic in research. Recently, the association between APN and thyroid cancer has received increasing attention. The purpose of this review is to systematically review previous studies, give prominence to APN, focus on the relationship between APN, obesity and thyroid cancer, and uncover the underlying pathogenic mechanisms.