METABOLISM OF TETRAHYDROCANNABINOL IN FREQUENT AND INFREQUENT MARIJUANA USERS
METABOLISM OF TETRAHYDROCANNABINOL IN FREQUENT AND INFREQUENT MARIJUANA USERS
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DOI：
10.1093/jat/16.4.228
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发表时间：
1992-07-01
影响因子：
2.5
通讯作者：
JONES, RT
中科院分区：
文献类型：
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作者：
KELLY, P;JONES, RT
在频繁和不频繁的大麻使用者静脉注射 5 mg THC 后，通过 GC/MS 测量血浆中的 Δ9 四氢大麻酚 (THC)、11-正-9-羧基-Δ9-四氢大麻酚 (THC-COOH) 及其 O-酯葡萄糖醛酸苷，并通过 GC/MS 和酶免疫测定法测量尿液中的Δ9四氢大麻酚 (THC)、11-正-9-羧基-Δ9-四氢大麻酚 (THC-COOH) 及其 O-酯葡萄糖醛酸苷。输注后 4-5 小时可使用固相柱进行药物提取并使用气相色谱/质谱 (GC/MS) 进行检测和定量，检测血浆 THC 浓度。 THC-COOH 及其 O-酯葡萄糖苷酸分析了 12 天。经常吸食大麻的人血浆和尿液中的浓度较高。输注后 2 至 30 分钟，频繁和不频繁使用者的血浆中 THC-COOH 与其 O-酯葡萄糖苷酸的比率均大于 2。随后 12 天的比率小于 2。对于频繁使用者和不频繁使用者，总 THC-COOH/THC 比率仅在 45 分钟之前才出现小于 1。生理、心理和药代动力学数据显示，经常吸食大麻和不经常吸食大麻的人之间几乎没有差异。
Δ9tetrahydrocannabinol (THC), 11-nor-9-carboxy-Δ9-tetra- hydrocannabinol (THC-COOH), and its O-ester glucuronide were measured in plasma by GC/MS and in urine by GC/MS and enzyme immunoassay after frequent and infrequent marijuana users were given 5 mg THC intravenously. Plasma THC concentrations were detectable 4–5 h after infusion using solid-phase columns for drug extraction and gas chromatography/mass spectrometry (GC/MS) for detection and quantification. THC-COOH and its O-ester glucuronide were analyzed for 12 days. Concentrations were higher in the plasma and urine of frequent marijuana users. The ratio of THC-COOH to its O-ester glucuronide in plasma was greater than 2 in both frequent and infrequent users 2 to 30 min postinfusion. Ratios for the subsequent 12 days were less than 2. A ratio of less than 1 for total THC-COOH/THC occurred only before 45 min for both frequent and infrequent users. Physiological, psychological, and pharmacokinetic data revealed few differences between frequent and infrequent marijuana users.