Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis
Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis
复制标题
单核细胞趋化蛋白-1基因2518A/G多态性与2型糖尿病视网膜病变的关联：荟萃分析
DOI：
10.1016/j.diabres.2016.07.016
复制
发表时间：
2016
影响因子：
5.1
通讯作者：
Huang Wenyong
中科院分区：
文献类型：
--
作者：
Wang Wei;He Miao;Huang Wenyong
目的单核细胞趋化蛋白-1(MCP-1)2518A/G基因多态性与糖尿病视网膜病变(DR)的关系近年来引起广泛关注，但报道结果存在争议。方法从PubMed、Embase、Web of Science、中文生物医学数据库和检索文献的参考文献中筛选出与2型糖尿病DR易感性相关的MCP-1基因多态性研究。通过固定或随机效应模型计算合并优势比(OR)及其95%可信区间(95%CI)。结果最终Meta分析包括6项研究，涉及3415名无DR和3468名有DR的患者。每5项研究分别评估MCP-1基因多态性与任何DR和增殖性DR(PDR)的相关性。固定模型Meta分析显示，单核细胞趋化蛋白-1基因多态性与糖尿病视网膜病变在纯合子模型(OR=1.36；95%CI：1.15~1.62，P&0.001)、杂合子模型(OR=1.20；95%CI：1.02~1.42，P=0.031)、显性模型(OR=1.28；95%CI：1.10~1.50，P=0.002)、隐性模型(OR=1.17；等位基因模式(OR=1.16；95%CI：1.07~1.25，P=0.001)。此外，在杂合子模型下，单核细胞趋化蛋白-1基因多态性与DR从非增殖性DR向增殖性DR进展显著相关(OR=1.45；95%CI：1.0 4~2.0 2，P=0.0.030)。结论对已有数据的Meta分析表明，MCP-1 2518 A/G基因多态性影响2型糖尿病糖尿病视网膜病变的发生和进展。
AimsThe relationship between monocyte chemoattractant protein-1 (MCP-1) 2518 A/G polymorphism and diabetic retinopathy (DR) attracted intense interest recently, but the reported results are controversial. A meta-analysis was performed to assess the MCP-1 polymorphism associated with DR susceptibility in type 2 diabetes mellitus.MethodsEligible studies were identified from PubMed, Embase, Web of science, Chinese Biomedical database, and references of retrieved articles. Pooled odds ratios (ORs) with their 95% confidence intervals (95%CI) were calculated by fixed or random-effects models.ResultsSix studies involving 3415 patients without DR and 3468 with any DR were included in the final meta-analysis. Each 5 studies evaluated the associations of MCP-1 polymorphism and any DR and proliferative DR (PDR), respectively. Meta-analysis in fixed model demonstrated a significant association between MCP-1 polymorphism and any DR under the homozygous model (OR = 1.36; 95%CI: 1.15–1.62,P< 0.001), heterozygous model (OR = 1.20; 95%CI: 1.02–1.42,P= 0.031), dominant model (OR = 1.28; 95%CI: 1.10–1.50,P= 0.002), recessive model (OR = 1.17; 95%CI: 1.05–1.31,P= 0.004), and allelic model (OR = 1.16; 95%CI: 1.07–1.25,P< 0.001). Furthermore, a significant association of MCP-1 polymorphism and DR progression from non-proliferative DR to proliferative DR was identified under heterozygous model (OR = 1.45; 95%CI: 1.04–2.02,P= 0.030). Sensitivity analyses did not draw different findings.ConclusionsMeta-analysis of existing data suggested that MCP-1 2518 A/G polymorphism affected the risk of presence and progression of DR in type 2 diabetes mellitus.