THE RELATIONSHIP BETWEEN P300 AMPLITUDE AND REGIONAL GRAY-MATTER VOLUMES DEPENDS UPON THE ATTENTIONAL SYSTEM ENGAGED
THE RELATIONSHIP BETWEEN P300 AMPLITUDE AND REGIONAL GRAY-MATTER VOLUMES DEPENDS UPON THE ATTENTIONAL SYSTEM ENGAGED
复制标题
DOI：
10.1016/0013-4694(94)90093-0
复制
发表时间：
1994-03-01
期刊：
影响因子：
--
通讯作者：
PFEFFERBAUM, A
中科院分区：
文献类型：
--
作者：
FORD, JM;SULLIVAN, EV;PFEFFERBAUM, A
对28例21~60岁正常男性进行了事件相关电位(ERPs)和脑磁共振成像(MRI)检查。在3个旨在引起自动或努力注意的范例以及两者的组合中记录事件相关电位。大脑灰质、白质和脑脊液(CSF)体积的MRI测量从额叶、顶叶和颞叶计算出来。P300波幅与灰质体积显著相关，与脑白质或脑脊液体积无相关性。此外，P300波幅和灰质体积之间的关系反映的是功能关系而不是直接的地形图关系：自动引起注意时在PZ记录的P300与额叶灰质体积显著相关，在努力注意时记录的P300与顶叶灰质体积显著相关，在两种注意调用时记录的P300与额叶和顶叶灰质体积显著相关。惊恐眨眼也是在自动吸引注意力的范例中引起的，与额叶灰质体积显著相关，但与顶叶灰质体积无关。没有证据表明P300波幅与记录电极下方灰质体积之间存在直接的空间关系。
Event-related potentials (ERPs) and brain magnetic resonance images (MRIs) were acquired from 28 normal men, age 21-60 years. ERPs were recorded during 3 paradigms designed to elicit automatic or effortful attention, and a combination of both. MRI-derived measures of brain gray matter, white matter and cerebral spinal fluid (CSF) volumes were computed from frontal, parietal and temporal lobes. P300 amplitude correlated significantly with gray matter volumes but not with white matter or CSF volumes. Furthermore, the relationships between P300 amplitude and gray matter volumes reflected functional rather than direct topographical relationships: P300 recorded at Pz during automatically elicited attention correlated significantly with frontal but not parietal lobe gray matter volumes, P300 recorded during effortful attention correlated significantly with parietal but not frontal lobe gray matter volumes, and P300 recorded when both types of attention were invoked correlated significantly with both frontal and parietal gray matter volumes. Startle blinks, also elicited during automatic attention-engaging paradigms, were significantly correlated with frontal but not parietal lobe gray matter volumes. There was no evidence for a direct spatial relationship between P300 amplitude and the gray matter volumes underlying the recording electrode.