Long-term prognosis of stage I ovarian carcinoma - Prognostic importance of intraoperative rupture
Long-term prognosis of stage I ovarian carcinoma - Prognostic importance of intraoperative rupture
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DOI：
10.1159/000071202
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Mizutani, S
中科院分区：
文献类型：
--
作者：
Mizuno, M;Kikkawa, F;Mizutani, S
目的：有一些对I期卵巢癌患者的长期随访研究。本研究的目的是评估长期生存的预后因素。方法：对1988 ~ 1999年东海卵巢肿瘤研究组登记的214例I期卵巢癌进行分析。根据国际妇产科联合会的分期，不考虑淋巴结的病理结果。Ic期分为Ic（B）期和其它Ic期。结果：1a期74例，1B期2例，Ic期138例，其中Ic期（B）75例，其他Ic期63例。在所分析的组织学类型中，透明细胞腺癌中Ic期与Ia期和Ic期（B）与Ic期的比率最高。各组间无病生存曲线有显著差异。在透明细胞腺癌中，Ic期（B）和其他Ic期之间的无病生存曲线存在显著差异（p = 0.0373），而这种趋势在除粘液癌外的其他组织学类型中也观察到。多因素分析显示，分期是无病生存期和总生存期的重要预后因素。结论：Ic期（B）患者的生存率低于Ia期患者，但优于其他Ic期患者。因此，在手术中谨慎处理卵巢肿瘤是非常重要的，以避免破裂。版权所有（C）2003 S. Karger AG，巴塞尔。
Objective:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for longterm survival. Methods: Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were analyzed. Staging according to the International Federation of Gynecology and Obstetrics was set without considering the pathologic findings of the lymph nodes. Stage Ic was divided into Ic(b) and other Ic. Results: Seventy-four patients were stage 1a, 2 were stage 1b, and 138 were stage Ic, consisting of 75 Ic(b) and 63 other Ic patients. The ratios of stage Ic to la and stage Ic(b) to Ic were highest in clear-cell adenocarcinoma among histologies analyzed. There were significant differences in disease-free survival curves between each group. In clear cell adenocarcinoma, there was a significant difference in disease-free survival curves between stage Ic(b) and other Ic (p = 0.0373), while this tendency was also observed in other histologies except for mucinous carcinoma. Multivariate analysis demonstrated that substage was a significant prognostic factor of both disease-free and overall survival. Conclusions: Stage Ic(b) patients showed poorer survival than stage la patients but better than survival in other Ic. Thus, cautious treatment of ovarian tumor during surgery is quite important to avoid rupture. Copyright (C) 2003 S. Karger AG, Basel.